Synthesis and study of norfloxacin labeled with technecium-99m as a potential imaging agent of bacterial inflammations

Abstract

Investigations have been carried out into creation of reagent for ^99mTc-labeled norfloxacin hydrochloride (NFH). The NFH synthesized in the Institute of Organic Synthesis (Ekaterinburg, Russia) was used in this research. The effect of the mixture components on the radiochemical specimen purity was assessed using the method of thin-layer chromatography. The inflammation animal model was used to demonstrate the NFH functional eligibility for diagnostics of inflammatory processes.

Original language	English
Title of host publication	Key Engineering Materials
Publisher	Trans Tech Publications Ltd
Pages	798-802
Number of pages	5
Volume	685
ISBN (Print)	9783038357087
DOIs	https://doi.org/10.4028/www.scientific.net/KEM.685.798
Publication status	Published - 2016
Event	4th International Conference for Young Scientists High Technology: Research and Applications, HTRA 2015 - Tomsk, Russian Federation Duration: 21 Apr 2015 → 24 Apr 2015

Publication series

Name	Key Engineering Materials
Volume	685
ISSN (Print)	10139826

Other

Other	4th International Conference for Young Scientists High Technology: Research and Applications, HTRA 2015
Country	Russian Federation
City	Tomsk
Period	21.4.15 → 24.4.15

Keywords

Tc'
Bacterial infection
Norfloxacin hydrochloride (NFH)
Radionuclide diagnostics
RP 'Norfloxacin
Technecium-99m (Tc)

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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Cite this

Varlamova, NV., Skuridin, V. S., Sazonov, A. E., Sazonova, SI., Nesterov, E. A., & Larionova, L. A. (2016). Synthesis and study of norfloxacin labeled with technecium-99m as a potential imaging agent of bacterial inflammations. In Key Engineering Materials (Vol. 685, pp. 798-802). (Key Engineering Materials; Vol. 685). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/KEM.685.798

Synthesis and study of norfloxacin labeled with technecium-99m as a potential imaging agent of bacterial inflammations. / Varlamova, Natalia Valerievna ; Skuridin, V. S.; Sazonov, A. E.; Sazonova, Svetlana Ivanovna; Nesterov, Evgeny Alexandrovich; Larionova, L. A.

Key Engineering Materials. Vol. 685 Trans Tech Publications Ltd, 2016. p. 798-802 (Key Engineering Materials; Vol. 685).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Varlamova, NV , Skuridin, VS, Sazonov, AE, Sazonova, SI, Nesterov, EA & Larionova, LA 2016, Synthesis and study of norfloxacin labeled with technecium-99m as a potential imaging agent of bacterial inflammations. in Key Engineering Materials. vol. 685, Key Engineering Materials, vol. 685, Trans Tech Publications Ltd, pp. 798-802, 4th International Conference for Young Scientists High Technology: Research and Applications, HTRA 2015, Tomsk, Russian Federation, 21.4.15. https://doi.org/10.4028/www.scientific.net/KEM.685.798

Varlamova, Natalia Valerievna ; Skuridin, V. S. ; Sazonov, A. E. ; Sazonova, Svetlana Ivanovna ; Nesterov, Evgeny Alexandrovich ; Larionova, L. A. / Synthesis and study of norfloxacin labeled with technecium-99m as a potential imaging agent of bacterial inflammations. Key Engineering Materials. Vol. 685 Trans Tech Publications Ltd, 2016. pp. 798-802 (Key Engineering Materials).

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title = "Synthesis and study of norfloxacin labeled with technecium-99m as a potential imaging agent of bacterial inflammations",

abstract = "Investigations have been carried out into creation of reagent for 99mTc-labeled norfloxacin hydrochloride (NFH). The NFH synthesized in the Institute of Organic Synthesis (Ekaterinburg, Russia) was used in this research. The effect of the mixture components on the radiochemical specimen purity was assessed using the method of thin-layer chromatography. The inflammation animal model was used to demonstrate the NFH functional eligibility for diagnostics of inflammatory processes.",

keywords = "Tc', Bacterial infection, Norfloxacin hydrochloride (NFH), Radionuclide diagnostics, RP 'Norfloxacin, Technecium-99m (Tc)",

author = "Natalia Valerievna Varlamova and Skuridin, {V. S.} and Sazonov, {A. E.} and Svetlana Ivanovna Sazonova and Nesterov, {Evgeny Alexandrovich} and Larionova, {L. A.}",

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AU - Varlamova, Natalia Valerievna

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AU - Sazonova, Svetlana Ivanovna

AU - Nesterov, Evgeny Alexandrovich

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KW - Tc'

KW - Bacterial infection

KW - Norfloxacin hydrochloride (NFH)

KW - Radionuclide diagnostics

KW - RP 'Norfloxacin

KW - Technecium-99m (Tc)

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