Abstract
A group of new acetylenic derivatives of indole was synthesized by condensation of 2- and 3-iodoindoles with terminal acetylenes. 3-Iodoindole unsubstituted at the heteroatom is distinguished by an increased tendency to undergo deiodination under the reaction conditions. Chemical transformations of the synthesized acetylenic derivatives were carried out, proceeding with both the retention of and with the participation of the triple bond. In the intramolecular cyclization of vicinal, functionally substituted indolylacetylenes, a tendency is manifested to form six-membered heterocycles. A primary pharmacological investigation of the compounds obtained was carried out. Most of them are slightly toxic, several of the compounds display in high doses indications of neurotropic activity.
| Original language | English |
|---|---|
| Pages (from-to) | 120-127 |
| Number of pages | 8 |
| Journal | Bulletin of the Academy of Sciences of the USSR Division of Chemical Science |
| Volume | 39 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Chemistry(all)
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Synthesis and certain properties of acetylenylindoles. / Prikhod'ko, T. A.; Kurilenko, V. M.; Khlienko, Zh N.; Vasilevskii, S. F.; Shvartsberg, M. S.
In: Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, Vol. 39, No. 1, 01.01.1990, p. 120-127.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and certain properties of acetylenylindoles
AU - Prikhod'ko, T. A.
AU - Kurilenko, V. M.
AU - Khlienko, Zh N.
AU - Vasilevskii, S. F.
AU - Shvartsberg, M. S.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - A group of new acetylenic derivatives of indole was synthesized by condensation of 2- and 3-iodoindoles with terminal acetylenes. 3-Iodoindole unsubstituted at the heteroatom is distinguished by an increased tendency to undergo deiodination under the reaction conditions. Chemical transformations of the synthesized acetylenic derivatives were carried out, proceeding with both the retention of and with the participation of the triple bond. In the intramolecular cyclization of vicinal, functionally substituted indolylacetylenes, a tendency is manifested to form six-membered heterocycles. A primary pharmacological investigation of the compounds obtained was carried out. Most of them are slightly toxic, several of the compounds display in high doses indications of neurotropic activity.
AB - A group of new acetylenic derivatives of indole was synthesized by condensation of 2- and 3-iodoindoles with terminal acetylenes. 3-Iodoindole unsubstituted at the heteroatom is distinguished by an increased tendency to undergo deiodination under the reaction conditions. Chemical transformations of the synthesized acetylenic derivatives were carried out, proceeding with both the retention of and with the participation of the triple bond. In the intramolecular cyclization of vicinal, functionally substituted indolylacetylenes, a tendency is manifested to form six-membered heterocycles. A primary pharmacological investigation of the compounds obtained was carried out. Most of them are slightly toxic, several of the compounds display in high doses indications of neurotropic activity.
UR - http://www.scopus.com/inward/record.url?scp=34249926737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249926737&partnerID=8YFLogxK
U2 - 10.1007/BF00963015
DO - 10.1007/BF00963015
M3 - Article
AN - SCOPUS:34249926737
VL - 39
SP - 120
EP - 127
JO - Russian Chemical Bulletin
JF - Russian Chemical Bulletin
SN - 0568-5230
IS - 1
ER -