Synthesis and certain properties of acetylenylindoles

T. A. Prikhod'ko, V. M. Kurilenko, Zh N. Khlienko, S. F. Vasilevskii, M. S. Shvartsberg

Research output: Contribution to journalArticle

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Abstract

A group of new acetylenic derivatives of indole was synthesized by condensation of 2- and 3-iodoindoles with terminal acetylenes. 3-Iodoindole unsubstituted at the heteroatom is distinguished by an increased tendency to undergo deiodination under the reaction conditions. Chemical transformations of the synthesized acetylenic derivatives were carried out, proceeding with both the retention of and with the participation of the triple bond. In the intramolecular cyclization of vicinal, functionally substituted indolylacetylenes, a tendency is manifested to form six-membered heterocycles. A primary pharmacological investigation of the compounds obtained was carried out. Most of them are slightly toxic, several of the compounds display in high doses indications of neurotropic activity.

Original languageEnglish
Pages (from-to)120-127
Number of pages8
JournalBulletin of the Academy of Sciences of the USSR Division of Chemical Science
Volume39
Issue number1
DOIs
Publication statusPublished - 1 Jan 1990
Externally publishedYes

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Derivatives
Alkynes
Poisons
Cyclization
Condensation
indole

ASJC Scopus subject areas

  • Chemistry(all)

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Synthesis and certain properties of acetylenylindoles. / Prikhod'ko, T. A.; Kurilenko, V. M.; Khlienko, Zh N.; Vasilevskii, S. F.; Shvartsberg, M. S.

In: Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, Vol. 39, No. 1, 01.01.1990, p. 120-127.

Research output: Contribution to journalArticle

Prikhod'ko, T. A. ; Kurilenko, V. M. ; Khlienko, Zh N. ; Vasilevskii, S. F. ; Shvartsberg, M. S. / Synthesis and certain properties of acetylenylindoles. In: Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 1990 ; Vol. 39, No. 1. pp. 120-127.
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