Synthesis and biological characterization of 123I-labeled 15-(p-iodophenyl)-3-methylpentadecanoic acid

Yu N. Takhauova, V. S. Skuridin, B. K. Kudelin, V. M. Golovkov, Natalia Valerievna Varlamova, E. V. Makarova, V. I. Chernov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Experimental batches of iodine-123-labeled beta-methyl iodophenylpentadecanoic acid (123I-BMIPP) with an activity of 180 MBq/mL have been produced based on 123I extracted from enriched 122Te targets irradiated by accelerated deuterons at the R-7M cyclotron. It is shown that the radiochemical purity of 123I-BMIPP in EtOH solutions exceeds 96% at an acceptable content of the main chemical impurities (Cu, Te). The conditions of 123I-BMIPP dilution in human serum albumin (10%) solution for injection in experimental animals are determined. The biological behavior of the preparation in rats has been studied. It is established that 123I-BMIPP is characterized by pronounced accumulation in the heart. A qualitative scintigram of the rabbit heart was obtained and showed the possibility of external detection. It is established that it is possible to judge the viability of myocardium by measuring the amount of 123I-BMIPP accumulated in the heart.

Original languageEnglish
Pages (from-to)521-524
Number of pages4
JournalPharmaceutical Chemistry Journal
Volume43
Issue number9
DOIs
Publication statusPublished - Sep 2009

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Acids
Cyclotrons
Deuterium
Serum Albumin
Iodine
Myocardium
iodofiltic acid
Rabbits
Injections

Keywords

  • I
  • Myocardium
  • Scintigraphy

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Synthesis and biological characterization of 123I-labeled 15-(p-iodophenyl)-3-methylpentadecanoic acid. / Takhauova, Yu N.; Skuridin, V. S.; Kudelin, B. K.; Golovkov, V. M.; Varlamova, Natalia Valerievna; Makarova, E. V.; Chernov, V. I.

In: Pharmaceutical Chemistry Journal, Vol. 43, No. 9, 09.2009, p. 521-524.

Research output: Contribution to journalArticle

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AU - Takhauova, Yu N.

AU - Skuridin, V. S.

AU - Kudelin, B. K.

AU - Golovkov, V. M.

AU - Varlamova, Natalia Valerievna

AU - Makarova, E. V.

AU - Chernov, V. I.

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