Abstract
A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms hydrogen bond with a solvating ethanol molecule. Biological activity of the synthesized hydrazones towards cathepsin Е and(or) elastase of human neutrophils has been determined.
Original language | English |
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Pages (from-to) | 2299-2306 |
Number of pages | 8 |
Journal | Russian Journal of General Chemistry |
Volume | 87 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Oct 2017 |
Keywords
- cathepsin Е
- hydrazone
- hydroxybenzoic acid hydrazide
- molecular docking
- neutrophil elastase
ASJC Scopus subject areas
- Chemistry(all)