Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide

Abstract

A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms hydrogen bond with a solvating ethanol molecule. Biological activity of the synthesized hydrazones towards cathepsin Е and(or) elastase of human neutrophils has been determined.

Original language	English
Pages (from-to)	2299-2306
Number of pages	8
Journal	Russian Journal of General Chemistry
Volume	87
Issue number	10
DOIs	https://doi.org/10.1134/S1070363217100097
Publication status	Published - 1 Oct 2017

Keywords

cathepsin Е
hydrazone
hydroxybenzoic acid hydrazide
molecular docking
neutrophil elastase

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1134/S1070363217100097

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Nurkenov, O. A., Satpaeva, Z. B., Schepetkin, I. A., Khlebnikov, A. I., Turdybekov, K. M., Seilkhanov, T. M., & Fazylov, S. D. (2017). Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide. Russian Journal of General Chemistry, 87(10), 2299-2306. https://doi.org/10.1134/S1070363217100097

Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide. / Nurkenov, O. A.; Satpaeva, Zh B.; Schepetkin, I. A.; Khlebnikov, A. I.; Turdybekov, K. M.; Seilkhanov, T. M.; Fazylov, S. D.

In: Russian Journal of General Chemistry, Vol. 87, No. 10, 01.10.2017, p. 2299-2306.

Research output: Contribution to journal › Article › peer-review

Nurkenov, OA, Satpaeva, ZB, Schepetkin, IA , Khlebnikov, AI, Turdybekov, KM, Seilkhanov, TM & Fazylov, SD 2017, 'Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide', Russian Journal of General Chemistry, vol. 87, no. 10, pp. 2299-2306. https://doi.org/10.1134/S1070363217100097

Nurkenov, O. A. ; Satpaeva, Zh B. ; Schepetkin, I. A. ; Khlebnikov, A. I. ; Turdybekov, K. M. ; Seilkhanov, T. M. ; Fazylov, S. D. / Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide. In: Russian Journal of General Chemistry. 2017 ; Vol. 87, No. 10. pp. 2299-2306.

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abstract = "A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms hydrogen bond with a solvating ethanol molecule. Biological activity of the synthesized hydrazones towards cathepsin Е and(or) elastase of human neutrophils has been determined.",

keywords = "cathepsin Е, hydrazone, hydroxybenzoic acid hydrazide, molecular docking, neutrophil elastase",

author = "Nurkenov, {O. A.} and Satpaeva, {Zh B.} and Schepetkin, {I. A.} and Khlebnikov, {A. I.} and Turdybekov, {K. M.} and Seilkhanov, {T. M.} and Fazylov, {S. D.}",

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AU - Satpaeva, Zh B.

AU - Schepetkin, I. A.

AU - Khlebnikov, A. I.

AU - Turdybekov, K. M.

AU - Seilkhanov, T. M.

AU - Fazylov, S. D.

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AB - A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms hydrogen bond with a solvating ethanol molecule. Biological activity of the synthesized hydrazones towards cathepsin Е and(or) elastase of human neutrophils has been determined.

KW - cathepsin Е

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KW - hydroxybenzoic acid hydrazide

KW - molecular docking

KW - neutrophil elastase

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