Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide

O. A. Nurkenov, Zh B. Satpaeva, I. A. Schepetkin, A. I. Khlebnikov, K. M. Turdybekov, T. M. Seilkhanov, S. D. Fazylov

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms hydrogen bond with a solvating ethanol molecule. Biological activity of the synthesized hydrazones towards cathepsin Е and(or) elastase of human neutrophils has been determined.

Original languageEnglish
Pages (from-to)2299-2306
Number of pages8
JournalRussian Journal of General Chemistry
Volume87
Issue number10
DOIs
Publication statusPublished - 1 Oct 2017

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Hydroxybenzoates
Hydrazones
Bioactivity
Cathepsins
Molecules
Pancreatic Elastase
X ray diffraction analysis
Hydrogen bonds
Ethanol
4-hydroxybenzoic acid hydrazide

Keywords

  • cathepsin Е
  • hydrazone
  • hydroxybenzoic acid hydrazide
  • molecular docking
  • neutrophil elastase

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide. / Nurkenov, O. A.; Satpaeva, Zh B.; Schepetkin, I. A.; Khlebnikov, A. I.; Turdybekov, K. M.; Seilkhanov, T. M.; Fazylov, S. D.

In: Russian Journal of General Chemistry, Vol. 87, No. 10, 01.10.2017, p. 2299-2306.

Research output: Contribution to journal › Article

Nurkenov, OA, Satpaeva, ZB, Schepetkin, IA, Khlebnikov, AI, Turdybekov, KM, Seilkhanov, TM & Fazylov, SD 2017, 'Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide', Russian Journal of General Chemistry, vol. 87, no. 10, pp. 2299-2306. https://doi.org/10.1134/S1070363217100097
Nurkenov OA, Satpaeva ZB, Schepetkin IA, Khlebnikov AI, Turdybekov KM, Seilkhanov TM et al. Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide. Russian Journal of General Chemistry. 2017 Oct 1;87(10):2299-2306. https://doi.org/10.1134/S1070363217100097
Nurkenov, O. A. ; Satpaeva, Zh B. ; Schepetkin, I. A. ; Khlebnikov, A. I. ; Turdybekov, K. M. ; Seilkhanov, T. M. ; Fazylov, S. D. / Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide. In: Russian Journal of General Chemistry. 2017 ; Vol. 87, No. 10. pp. 2299-2306.
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AU - Schepetkin, I. A.

AU - Khlebnikov, A. I.

AU - Turdybekov, K. M.

AU - Seilkhanov, T. M.

AU - Fazylov, S. D.

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