Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide

O. A. Nurkenov, Zh B. Satpaeva, I. A. Schepetkin, A. I. Khlebnikov, K. M. Turdybekov, T. M. Seilkhanov, S. D. Fazylov

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms hydrogen bond with a solvating ethanol molecule. Biological activity of the synthesized hydrazones towards cathepsin Е and(or) elastase of human neutrophils has been determined.

Original languageEnglish
Pages (from-to)2299-2306
Number of pages8
JournalRussian Journal of General Chemistry
Volume87
Issue number10
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • cathepsin Е
  • hydrazone
  • hydroxybenzoic acid hydrazide
  • molecular docking
  • neutrophil elastase

ASJC Scopus subject areas

  • Chemistry(all)

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