Abstract
A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms hydrogen bond with a solvating ethanol molecule. Biological activity of the synthesized hydrazones towards cathepsin Е and(or) elastase of human neutrophils has been determined.
| Original language | English |
|---|---|
| Pages (from-to) | 2299-2306 |
| Number of pages | 8 |
| Journal | Russian Journal of General Chemistry |
| Volume | 87 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1 Oct 2017 |
Keywords
- cathepsin Е
- hydrazone
- hydroxybenzoic acid hydrazide
- molecular docking
- neutrophil elastase
ASJC Scopus subject areas
- Chemistry(all)
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Nurkenov, O. A., Satpaeva, Z. B., Schepetkin, I. A., Khlebnikov, A. I., Turdybekov, K. M., Seilkhanov, T. M., & Fazylov, S. D. (2017). Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide. Russian Journal of General Chemistry, 87(10), 2299-2306. https://doi.org/10.1134/S1070363217100097