Synthesis and antitumor activity of 7-(triazol-1-yl)pyrroloallocolchicine derivatives

N. S. Sitnikov, A. V. Sintsov, E. S. Shchegravina, A. Prokop, H. G. Schmalz, V. V. Fokin, A. Yu Fedorov

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2 Citations (Scopus)

Abstract

The cycloaddition of acetylene derivatives of azido-substituted pyrroloallocolchicines afforded 7-(triazol-1-yl)pyrroloallocolchicines. The synthesized compounds exhibit considerable cytotoxicity and apoptosis-inducing activity against Nalm 6 human leukemia cells.

Original languageEnglish
Pages (from-to)1362-1368
Number of pages7
JournalRussian Chemical Bulletin
Volume64
Issue number6
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

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Keywords

  • allocolchicines
  • antitumor activity
  • dipolar cycloaddition
  • triazoles

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Sitnikov, N. S., Sintsov, A. V., Shchegravina, E. S., Prokop, A., Schmalz, H. G., Fokin, V. V., & Fedorov, A. Y. (2015). Synthesis and antitumor activity of 7-(triazol-1-yl)pyrroloallocolchicine derivatives. Russian Chemical Bulletin, 64(6), 1362-1368. https://doi.org/10.1007/s11172-015-1018-z