Synthesis and antitumor activity of 7-(triazol-1-yl)pyrroloallocolchicine derivatives

N. S. Sitnikov, A. V. Sintsov, E. S. Shchegravina, A. Prokop, H. G. Schmalz, V. V. Fokin, A. Yu Fedorov

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The cycloaddition of acetylene derivatives of azido-substituted pyrroloallocolchicines afforded 7-(triazol-1-yl)pyrroloallocolchicines. The synthesized compounds exhibit considerable cytotoxicity and apoptosis-inducing activity against Nalm 6 human leukemia cells.

Original languageEnglish
Pages (from-to)1362-1368
Number of pages7
JournalRussian Chemical Bulletin
Volume64
Issue number6
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Keywords

  • allocolchicines
  • antitumor activity
  • dipolar cycloaddition
  • triazoles

ASJC Scopus subject areas

  • Chemistry(all)

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