Synthesis and antioxidant evaluation of some new allobetulin esters

Abstract

A series of 3-O-haloacyl allobetulin were synthesized via acylation of allobetulin by haloacetic (trifluro,difluorochloro, trichloro, monochloro) acid in CHCl₃ at 70 °C. The structure of allobetulin was modified at C-3 position, and esters 3a-d were obtained in high yields. Moreover the reactions do not need a catalyst. The structures of all synthesized compounds were confirmed by various spectroscopic methods (IR and NMR) and tested for antioxidant activity.

Original language	English
Pages (from-to)	1032-1037
Number of pages	6
Journal	Rasayan Journal of Chemistry
Volume	12
Issue number	3
DOIs	https://doi.org/10.31788/RJC.2019.1235159
Publication status	Published - 2019

Keywords

Allobetulin
Antioxidant
Betulin
Esterification
Haloacetic acid
Triterpene

ASJC Scopus subject areas

Chemistry(all)
Biochemistry
Chemical Engineering(all)
Energy(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.31788/RJC.2019.1235159

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@article{0ce9741c25bb4bba8e38f76be092e673,

title = "Synthesis and antioxidant evaluation of some new allobetulin esters",

abstract = "A series of 3-O-haloacyl allobetulin were synthesized via acylation of allobetulin by haloacetic (trifluro,difluorochloro, trichloro, monochloro) acid in CHCl3 at 70 °C. The structure of allobetulin was modified at C-3 position, and esters 3a-d were obtained in high yields. Moreover the reactions do not need a catalyst. The structures of all synthesized compounds were confirmed by various spectroscopic methods (IR and NMR) and tested for antioxidant activity.",

keywords = "Allobetulin, Antioxidant, Betulin, Esterification, Haloacetic acid, Triterpene",

author = "S. Arrous and I. Boudebouz and O. Voronova and E. Plotnikov and A. Bakibaev",

note = "Funding Information: This research was supported and financed Federation (Grant No. 05-13108). Funding Information: This research was supported and financed by the Ministry of Education and Science of the Russian Federation (Grant No. 05-13108). Publisher Copyright: {\textcopyright} RASĀYAN. All rights reserved. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "2019",

doi = "10.31788/RJC.2019.1235159",

language = "English",

volume = "12",

pages = "1032--1037",

journal = "Rasayan Journal of Chemistry",

issn = "0974-1496",

publisher = "Rasayan Journal",

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TY - JOUR

T1 - Synthesis and antioxidant evaluation of some new allobetulin esters

AU - Arrous, S.

AU - Boudebouz, I.

AU - Voronova, O.

AU - Plotnikov, E.

AU - Bakibaev, A.

N1 - Funding Information: This research was supported and financed Federation (Grant No. 05-13108). Funding Information: This research was supported and financed by the Ministry of Education and Science of the Russian Federation (Grant No. 05-13108). Publisher Copyright: © RASĀYAN. All rights reserved. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019

Y1 - 2019

N2 - A series of 3-O-haloacyl allobetulin were synthesized via acylation of allobetulin by haloacetic (trifluro,difluorochloro, trichloro, monochloro) acid in CHCl3 at 70 °C. The structure of allobetulin was modified at C-3 position, and esters 3a-d were obtained in high yields. Moreover the reactions do not need a catalyst. The structures of all synthesized compounds were confirmed by various spectroscopic methods (IR and NMR) and tested for antioxidant activity.

AB - A series of 3-O-haloacyl allobetulin were synthesized via acylation of allobetulin by haloacetic (trifluro,difluorochloro, trichloro, monochloro) acid in CHCl3 at 70 °C. The structure of allobetulin was modified at C-3 position, and esters 3a-d were obtained in high yields. Moreover the reactions do not need a catalyst. The structures of all synthesized compounds were confirmed by various spectroscopic methods (IR and NMR) and tested for antioxidant activity.

KW - Allobetulin

KW - Antioxidant

KW - Betulin

KW - Esterification

KW - Haloacetic acid

KW - Triterpene

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DO - 10.31788/RJC.2019.1235159

M3 - Article

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SP - 1032

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JO - Rasayan Journal of Chemistry

JF - Rasayan Journal of Chemistry

SN - 0974-1496

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