TY - JOUR
T1 - Synthesis and antioxidant activity of some new thioglycoluril derivatives
AU - Boudebouz, Imene
AU - Arrous, Salah
AU - Plotnikov, Evgenii
AU - Voronova, Olesya
AU - Bakibaev, Abdigali
PY - 2019/1/1
Y1 - 2019/1/1
N2 -
A series of S-alkylated products was prepared by alkylation of thioglycoluril with various alkylation agents, i.e. ethyl bromide, ethylene dibromide and chloroacetic acid. The synthesis performed in DMF at 60°C using sodium hydroxide as a base to give the corresponding products with significant advantages such as high conversions, short reaction time, mild reaction conditions, and low cost, simple workup with moderate to excellent yields. The structures of the synthesized compounds have been deduced from their spectral (IR,
1
H-NMR and
13
C-NMR) data. Significant antioxidant activity was observed for some members of the series.
AB -
A series of S-alkylated products was prepared by alkylation of thioglycoluril with various alkylation agents, i.e. ethyl bromide, ethylene dibromide and chloroacetic acid. The synthesis performed in DMF at 60°C using sodium hydroxide as a base to give the corresponding products with significant advantages such as high conversions, short reaction time, mild reaction conditions, and low cost, simple workup with moderate to excellent yields. The structures of the synthesized compounds have been deduced from their spectral (IR,
1
H-NMR and
13
C-NMR) data. Significant antioxidant activity was observed for some members of the series.
KW - alkyl halides
KW - alkylation
KW - antioxidant activity
KW - thioamides
KW - Thioglycoluril
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U2 - 10.1080/17415993.2019.1588897
DO - 10.1080/17415993.2019.1588897
M3 - Article
AN - SCOPUS:85063080178
JO - Journal of Sulfur Chemistry
JF - Journal of Sulfur Chemistry
SN - 1741-5993
ER -