Synthesis and antioxidant activity of some new thioglycoluril derivatives

Imene Boudebouz, Salah Arrous, Evgenii Plotnikov, Olesya Voronova, Abdigali Bakibaev

Research output: Contribution to journalArticlepeer-review


A series of S-alkylated products was prepared by alkylation of thioglycoluril with various alkylation agents, i.e. ethyl bromide, ethylene dibromide and chloroacetic acid. The synthesis performed in DMF at 60°C using sodium hydroxide as a base to give the corresponding products with significant advantages such as high conversions, short reaction time, mild reaction conditions, and low cost, simple workup with moderate to excellent yields. The structures of the synthesized compounds have been deduced from their spectral (IR, 1 H-NMR and 13 C-NMR) data. Significant antioxidant activity was observed for some members of the series.

Original languageEnglish
JournalJournal of Sulfur Chemistry
Publication statusPublished - 1 Jan 2019


  • alkyl halides
  • alkylation
  • antioxidant activity
  • thioamides
  • Thioglycoluril

ASJC Scopus subject areas

  • Chemistry(all)

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