Synthesis and antioxidant activity of some new thioglycoluril derivatives

Imene Boudebouz, Salah Arrous, Evgenii Plotnikov, Olesya Voronova, Abdigali Bakibaev

Research output: Contribution to journal › Article

Abstract

A series of S-alkylated products was prepared by alkylation of thioglycoluril with various alkylation agents, i.e. ethyl bromide, ethylene dibromide and chloroacetic acid. The synthesis performed in DMF at 60°C using sodium hydroxide as a base to give the corresponding products with significant advantages such as high conversions, short reaction time, mild reaction conditions, and low cost, simple workup with moderate to excellent yields. The structures of the synthesized compounds have been deduced from their spectral (IR, 1 H-NMR and 13 C-NMR) data. Significant antioxidant activity was observed for some members of the series.

Original languageEnglish
JournalJournal of Sulfur Chemistry
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Alkylation
Antioxidants
Ethylene Dibromide
Nuclear magnetic resonance
Derivatives
Sodium Hydroxide
Costs
chloroacetic acid

Keywords

  • alkyl halides
  • alkylation
  • antioxidant activity
  • thioamides
  • Thioglycoluril

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Synthesis and antioxidant activity of some new thioglycoluril derivatives. / Boudebouz, Imene; Arrous, Salah; Plotnikov, Evgenii; Voronova, Olesya; Bakibaev, Abdigali.

In: Journal of Sulfur Chemistry, 01.01.2019.

Research output: Contribution to journal › Article

Boudebouz, I, Arrous, S, Plotnikov, E, Voronova, O & Bakibaev, A 2019, 'Synthesis and antioxidant activity of some new thioglycoluril derivatives', Journal of Sulfur Chemistry. https://doi.org/10.1080/17415993.2019.1588897
Boudebouz I, Arrous S, Plotnikov E, Voronova O, Bakibaev A. Synthesis and antioxidant activity of some new thioglycoluril derivatives. Journal of Sulfur Chemistry. 2019 Jan 1. https://doi.org/10.1080/17415993.2019.1588897
Boudebouz, Imene ; Arrous, Salah ; Plotnikov, Evgenii ; Voronova, Olesya ; Bakibaev, Abdigali. / Synthesis and antioxidant activity of some new thioglycoluril derivatives. In: Journal of Sulfur Chemistry. 2019.
@article{95e30a25331b4a609e0f7cb9e5fd440e,
title = "Synthesis and antioxidant activity of some new thioglycoluril derivatives",
abstract = "A series of S-alkylated products was prepared by alkylation of thioglycoluril with various alkylation agents, i.e. ethyl bromide, ethylene dibromide and chloroacetic acid. The synthesis performed in DMF at 60°C using sodium hydroxide as a base to give the corresponding products with significant advantages such as high conversions, short reaction time, mild reaction conditions, and low cost, simple workup with moderate to excellent yields. The structures of the synthesized compounds have been deduced from their spectral (IR, 1 H-NMR and 13 C-NMR) data. Significant antioxidant activity was observed for some members of the series.",
keywords = "alkyl halides, alkylation, antioxidant activity, thioamides, Thioglycoluril",
author = "Imene Boudebouz and Salah Arrous and Evgenii Plotnikov and Olesya Voronova and Abdigali Bakibaev",
year = "2019",
month = "1",
day = "1",
doi = "10.1080/17415993.2019.1588897",
language = "English",
journal = "Journal of Sulfur Chemistry",
issn = "1741-5993",
publisher = "Taylor and Francis Ltd.",

}

TY - JOUR

T1 - Synthesis and antioxidant activity of some new thioglycoluril derivatives

AU - Boudebouz, Imene

AU - Arrous, Salah

AU - Plotnikov, Evgenii

AU - Voronova, Olesya

AU - Bakibaev, Abdigali

PY - 2019/1/1

Y1 - 2019/1/1

N2 - A series of S-alkylated products was prepared by alkylation of thioglycoluril with various alkylation agents, i.e. ethyl bromide, ethylene dibromide and chloroacetic acid. The synthesis performed in DMF at 60°C using sodium hydroxide as a base to give the corresponding products with significant advantages such as high conversions, short reaction time, mild reaction conditions, and low cost, simple workup with moderate to excellent yields. The structures of the synthesized compounds have been deduced from their spectral (IR, 1 H-NMR and 13 C-NMR) data. Significant antioxidant activity was observed for some members of the series.

AB - A series of S-alkylated products was prepared by alkylation of thioglycoluril with various alkylation agents, i.e. ethyl bromide, ethylene dibromide and chloroacetic acid. The synthesis performed in DMF at 60°C using sodium hydroxide as a base to give the corresponding products with significant advantages such as high conversions, short reaction time, mild reaction conditions, and low cost, simple workup with moderate to excellent yields. The structures of the synthesized compounds have been deduced from their spectral (IR, 1 H-NMR and 13 C-NMR) data. Significant antioxidant activity was observed for some members of the series.

KW - alkyl halides

KW - alkylation

KW - antioxidant activity

KW - thioamides

KW - Thioglycoluril

UR - http://www.scopus.com/inward/record.url?scp=85063080178&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063080178&partnerID=8YFLogxK

U2 - 10.1080/17415993.2019.1588897

DO - 10.1080/17415993.2019.1588897

M3 - Article

AN - SCOPUS:85063080178

JO - Journal of Sulfur Chemistry

JF - Journal of Sulfur Chemistry

SN - 1741-5993

ER -

Access to Document