Synthesis and anti-inflammatory activity of ethynylthiazoles

A. Geronikaki, S. Vasilevsky, D. Hadjipavlou-Litina, A. Lagunin, B. V. Poroikov

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1 Citation (Scopus)

Abstract

A series of acetylene derivatives of thiazole using Sonogashira cross-coupling method was synthesized and evaluated in vivo for their anti-inflammatory activity. Four compounds exhibited a good anti-inflammatory activity and two inhibited soybean lipoxygenase.

Original languageEnglish
Pages (from-to)769-774
Number of pages6
JournalKhimiya Geterotsiklicheskikh Soedinenii
Issue number5
Publication statusPublished - 11 Jul 2006
Externally publishedYes

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Keywords

  • Anti-inflammatory
  • Ethynyl thiazoles
  • Lipoxygenase (LOX)

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Geronikaki, A., Vasilevsky, S., Hadjipavlou-Litina, D., Lagunin, A., & Poroikov, B. V. (2006). Synthesis and anti-inflammatory activity of ethynylthiazoles. Khimiya Geterotsiklicheskikh Soedinenii, (5), 769-774.