Synthesis and anti-inflammatory activity of ethynylthiazoles

A. Geronikaki, S. Vasilevsky, D. Hadjipavlou-Litina, A. Lagunin, B. V. Poroikov

Research output: Contribution to journal › Article › peer-review

Abstract

A series of acetylene derivatives of thiazole using Sonogashira cross-coupling method was synthesized and evaluated in vivo for their anti-inflammatory activity. Four compounds exhibited a good anti-inflammatory activity and two inhibited soybean lipoxygenase.

Original language	English
Pages (from-to)	769-774
Number of pages	6
Journal	Khimiya Geterotsiklicheskikh Soedinenii
Issue number	5
Publication status	Published - 11 Jul 2006
Externally published	Yes

Keywords

Anti-inflammatory
Ethynyl thiazoles
Lipoxygenase (LOX)

ASJC Scopus subject areas

Organic Chemistry

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title = "Synthesis and anti-inflammatory activity of ethynylthiazoles",

abstract = "A series of acetylene derivatives of thiazole using Sonogashira cross-coupling method was synthesized and evaluated in vivo for their anti-inflammatory activity. Four compounds exhibited a good anti-inflammatory activity and two inhibited soybean lipoxygenase.",

keywords = "Anti-inflammatory, Ethynyl thiazoles, Lipoxygenase (LOX)",

author = "A. Geronikaki and S. Vasilevsky and D. Hadjipavlou-Litina and A. Lagunin and Poroikov, {B. V.}",

year = "2006",

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language = "English",

pages = "769--774",

journal = "Khimiya Geterotsiklicheskikh Soedinenii",

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AU - Geronikaki, A.

AU - Vasilevsky, S.

AU - Hadjipavlou-Litina, D.

AU - Lagunin, A.

AU - Poroikov, B. V.

PY - 2006/7/11

Y1 - 2006/7/11

N2 - A series of acetylene derivatives of thiazole using Sonogashira cross-coupling method was synthesized and evaluated in vivo for their anti-inflammatory activity. Four compounds exhibited a good anti-inflammatory activity and two inhibited soybean lipoxygenase.

AB - A series of acetylene derivatives of thiazole using Sonogashira cross-coupling method was synthesized and evaluated in vivo for their anti-inflammatory activity. Four compounds exhibited a good anti-inflammatory activity and two inhibited soybean lipoxygenase.

KW - Anti-inflammatory

KW - Ethynyl thiazoles

KW - Lipoxygenase (LOX)

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SP - 769

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JO - Khimiya Geterotsiklicheskikh Soedinenii

JF - Khimiya Geterotsiklicheskikh Soedinenii

SN - 0132-6244

IS - 5

ER -

Synthesis and anti-inflammatory activity of ethynylthiazoles

Abstract

Keywords

ASJC Scopus subject areas

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