Synthesis and anti-inflammatory activity of ethynylthiazoles

A. Geronikaki, S. Vasilevsky, D. Hadjipavlou-Litina, A. Lagunin, B. V. Poroikov

Research output: Contribution to journal › Article

Abstract

A series of acetylene derivatives of thiazole using Sonogashira cross-coupling method was synthesized and evaluated in vivo for their anti-inflammatory activity. Four compounds exhibited a good anti-inflammatory activity and two inhibited soybean lipoxygenase.

Original language	English
Pages (from-to)	769-774
Number of pages	6
Journal	Khimiya Geterotsiklicheskikh Soedinenii
Issue number	5
Publication status	Published - 11 Jul 2006
Externally published	Yes

Fingerprint

Anti-Inflammatory Agents

Thiazoles

Acetylene

Lipoxygenase

Derivatives

Keywords

Anti-inflammatory
Ethynyl thiazoles
Lipoxygenase (LOX)

ASJC Scopus subject areas

Organic Chemistry

Cite this

Geronikaki, A., Vasilevsky, S., Hadjipavlou-Litina, D., Lagunin, A., & Poroikov, B. V. (2006). Synthesis and anti-inflammatory activity of ethynylthiazoles. Khimiya Geterotsiklicheskikh Soedinenii, (5), 769-774.

Synthesis and anti-inflammatory activity of ethynylthiazoles. / Geronikaki, A.; Vasilevsky, S.; Hadjipavlou-Litina, D.; Lagunin, A.; Poroikov, B. V.

In: Khimiya Geterotsiklicheskikh Soedinenii, No. 5, 11.07.2006, p. 769-774.

Research output: Contribution to journal › Article

Geronikaki, A, Vasilevsky, S, Hadjipavlou-Litina, D, Lagunin, A & Poroikov, BV 2006, 'Synthesis and anti-inflammatory activity of ethynylthiazoles', Khimiya Geterotsiklicheskikh Soedinenii, no. 5, pp. 769-774.

Geronikaki A, Vasilevsky S, Hadjipavlou-Litina D, Lagunin A, Poroikov BV. Synthesis and anti-inflammatory activity of ethynylthiazoles. Khimiya Geterotsiklicheskikh Soedinenii. 2006 Jul 11;(5):769-774.

Geronikaki, A. ; Vasilevsky, S. ; Hadjipavlou-Litina, D. ; Lagunin, A. ; Poroikov, B. V. / Synthesis and anti-inflammatory activity of ethynylthiazoles. In: Khimiya Geterotsiklicheskikh Soedinenii. 2006 ; No. 5. pp. 769-774.

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