Synthesis and anti-inflammatory activity of ethynylthiazoles

A. Geronikaki, S. Vasilevsky, D. Hadjipavlou-Litina, A. Lagunin, B. V. Poroikov

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A series of acetylene derivatives of thiazole using the Sonogashira cross-coupling method was synthesized and evaluated in vivo for their anti-inflammatory activity. Four compounds exhibited good anti-inflammatory activity and two inhibited soybean lipoxygenase.

Original languageEnglish
Pages (from-to)675-680
Number of pages6
JournalChemistry of Heterocyclic Compounds
Volume42
Issue number5
DOIs
Publication statusPublished - 1 May 2006
Externally publishedYes

Fingerprint

Anti-Inflammatory Agents
Thiazoles
Acetylene
Lipoxygenase
Derivatives

Keywords

  • Anti-inflammatory
  • Ethynylthiazoles
  • Lipoxygenase (LOX)

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis and anti-inflammatory activity of ethynylthiazoles. / Geronikaki, A.; Vasilevsky, S.; Hadjipavlou-Litina, D.; Lagunin, A.; Poroikov, B. V.

In: Chemistry of Heterocyclic Compounds, Vol. 42, No. 5, 01.05.2006, p. 675-680.

Research output: Contribution to journalArticle

Geronikaki, A, Vasilevsky, S, Hadjipavlou-Litina, D, Lagunin, A & Poroikov, BV 2006, 'Synthesis and anti-inflammatory activity of ethynylthiazoles', Chemistry of Heterocyclic Compounds, vol. 42, no. 5, pp. 675-680. https://doi.org/10.1007/s10593-006-0145-8
Geronikaki, A. ; Vasilevsky, S. ; Hadjipavlou-Litina, D. ; Lagunin, A. ; Poroikov, B. V. / Synthesis and anti-inflammatory activity of ethynylthiazoles. In: Chemistry of Heterocyclic Compounds. 2006 ; Vol. 42, No. 5. pp. 675-680.
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