Synthesis and anti-inflammatory activity of ethynylthiazoles

A. Geronikaki, S. Vasilevsky, D. Hadjipavlou-Litina, A. Lagunin, B. V. Poroikov

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A series of acetylene derivatives of thiazole using the Sonogashira cross-coupling method was synthesized and evaluated in vivo for their anti-inflammatory activity. Four compounds exhibited good anti-inflammatory activity and two inhibited soybean lipoxygenase.

Original languageEnglish
Pages (from-to)675-680
Number of pages6
JournalChemistry of Heterocyclic Compounds
Volume42
Issue number5
DOIs
Publication statusPublished - 1 May 2006
Externally publishedYes

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Keywords

  • Anti-inflammatory
  • Ethynylthiazoles
  • Lipoxygenase (LOX)

ASJC Scopus subject areas

  • Organic Chemistry

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