Surface Modification of PLLA Electrospun Nanofiber Materials for Biomedical Applications

Topic Issue on Nano&Micro: Particles, Films, Containers—VII

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1 Citation (Scopus)

Abstract

Three dimensional nanofiber materials made of poly-L-lactic acid (PLLA) and produced by electrospinning are commonly used in regenerative medicine and as a base for drug delivery systems. Surface modification of such materials allows manipulating their chemical, physical, and biological properties. Previously, our group reported a number of modification strategies for thin PLLA films, based on the “solvent/non-solvent” technique. Most biologically active agents may not be adsorbed on the surface of PLLA. Proposed treatment allows partially dissolving the polymer surface in order to adsorb biologically active molecules or linkers. The aim of this work was to investigate the influence of solvent/non-solvent mixture composition on the morphology and crystal structure of the electrospun PLLA scaffolds and to select the solvent system for further scaffolds modification in order to impart them biological activity. PLLA scaffolds were treated with mixtures of toluene and ethanol in different compositions. By means of scanning electron microscopy, it was shown that solvent/non-solvent treatment had no critical effect on the morphology of the scaffolds. The results of X-ray diffraction analysis revealed that treatment of the scaffolds with investigated solvent systems did not lead to the formation of the additional phases and the size of the polymer crystallites as well. Thus, selected solvent system will be used for modification of the PLLA electrospun nanofiber material for biomedical application.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalBioNanoScience
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Mar 2018

Fingerprint

Lactic acid
Nanofibers
Surface treatment
Scaffolds
Scaffolds (biology)
Polymers
Electrospinning
Toluene
Bioactivity
Chemical analysis
Crystallites
X ray diffraction analysis
poly(lactic acid)
Ethanol
Crystal structure
Scanning electron microscopy
Molecules

Keywords

  • Biodegradable scaffolds
  • PLLA
  • Poly-L-lactic acid
  • Surface modification

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

Cite this

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title = "Surface Modification of PLLA Electrospun Nanofiber Materials for Biomedical Applications: Topic Issue on Nano&Micro: Particles, Films, Containers—VII",
abstract = "Three dimensional nanofiber materials made of poly-L-lactic acid (PLLA) and produced by electrospinning are commonly used in regenerative medicine and as a base for drug delivery systems. Surface modification of such materials allows manipulating their chemical, physical, and biological properties. Previously, our group reported a number of modification strategies for thin PLLA films, based on the “solvent/non-solvent” technique. Most biologically active agents may not be adsorbed on the surface of PLLA. Proposed treatment allows partially dissolving the polymer surface in order to adsorb biologically active molecules or linkers. The aim of this work was to investigate the influence of solvent/non-solvent mixture composition on the morphology and crystal structure of the electrospun PLLA scaffolds and to select the solvent system for further scaffolds modification in order to impart them biological activity. PLLA scaffolds were treated with mixtures of toluene and ethanol in different compositions. By means of scanning electron microscopy, it was shown that solvent/non-solvent treatment had no critical effect on the morphology of the scaffolds. The results of X-ray diffraction analysis revealed that treatment of the scaffolds with investigated solvent systems did not lead to the formation of the additional phases and the size of the polymer crystallites as well. Thus, selected solvent system will be used for modification of the PLLA electrospun nanofiber material for biomedical application.",
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author = "Goreninskii, {S. I.} and Stankevich, {K. S.} and Bolbasov, {E. N.} and Danilenko, {N. V.} and Filimonov, {V. D.} and Tverdokhlebov, {S. I.}",
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AU - Goreninskii, S. I.

AU - Stankevich, K. S.

AU - Bolbasov, E. N.

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AU - Filimonov, V. D.

AU - Tverdokhlebov, S. I.

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AB - Three dimensional nanofiber materials made of poly-L-lactic acid (PLLA) and produced by electrospinning are commonly used in regenerative medicine and as a base for drug delivery systems. Surface modification of such materials allows manipulating their chemical, physical, and biological properties. Previously, our group reported a number of modification strategies for thin PLLA films, based on the “solvent/non-solvent” technique. Most biologically active agents may not be adsorbed on the surface of PLLA. Proposed treatment allows partially dissolving the polymer surface in order to adsorb biologically active molecules or linkers. The aim of this work was to investigate the influence of solvent/non-solvent mixture composition on the morphology and crystal structure of the electrospun PLLA scaffolds and to select the solvent system for further scaffolds modification in order to impart them biological activity. PLLA scaffolds were treated with mixtures of toluene and ethanol in different compositions. By means of scanning electron microscopy, it was shown that solvent/non-solvent treatment had no critical effect on the morphology of the scaffolds. The results of X-ray diffraction analysis revealed that treatment of the scaffolds with investigated solvent systems did not lead to the formation of the additional phases and the size of the polymer crystallites as well. Thus, selected solvent system will be used for modification of the PLLA electrospun nanofiber material for biomedical application.

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