Surface modification of electrospun poly-(L-lactic) acid scaffolds by reactive magnetron sputtering

E. N. Bolbasov, P. V. Maryin, K. S. Stankevich, A. I. Kozelskaya, E. V. Shesterikov, Yu I. Khodyrevskaya, M. V. Nasonova, D. K. Shishkova, Yu A. Kudryavtseva, Y. G. Anissimov, S. I. Tverdokhlebov

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

In this study, we modified the surface of bioresorbable electrospun poly-(L-lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity. No adverse tissue reaction up to 3 months after subcutaneous implantation of the modified scaffolds was detected in in-vivo rat model. The rate of scaffold replacement by the recipient tissue in-vivo was observed to depend on the plasma treatment time.

Original languageEnglish
Pages (from-to)43-51
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume162
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • Biocompatibility
  • Electrospun PLLA scaffold
  • Reactive magnetron sputtering

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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