Surface characterization and biological assessment of corrosion-resistant a-C:H:SiO<sub>x</sub> PACVD coating for Ti-6Al-4V alloy

Abstract

The paper focuses on the SiO_x-doped amorphous hydrocarbon (a-C:H:SiO_x) coating on the titanium (Ti-6Al-4V) alloy substrate obtained by plasma-assisted chemical vapor deposition (PACVD) in a mixture of argon gas and polyphenylmethylsiloxane vapor using a bipolar substrate bias. It is shown that the a-C:H:SiO_x coating deposition results in the formation of a negative surface potential important for application of this coating for medical implants. The a-C:H:SiO_x coatings improve the corrosion resistance of Ti alloy to 0.5 M NaCl solution and phosphate-buffered saline. In particular, the corrosion current density of the a-C:H:SiO_x-coated sample in a 0.5 M NaCl solution at 22 °C decreases from 1∙10⁻⁸ to 1.7∙10⁻¹⁰ A/cm², that reduces the corrosion rate from 9∙10⁻⁵ to 15∙10⁻⁷ mm/year. The a-C:H:SiO_x coating facilitates the surface endothelization of an implant located in the thoracic aorta of a mini pig, and reduces the risk of thrombosis and implant failure. This effect can be explained by the ability of the a-C:H:SiO_x coating ability to reduce in vitro a 24-hour secretion of pro-inflammatory interleukins (IL-6, IL-12(p70), IL-15, and IL-17) and cytokines (IFN-g and TNF-a) by blood mononuclear cells (MNCs) and elevates the concentration of anti-inflammatory interleukin IL-1Ra. In vitro analysis shows no cytotoxicity of the a-C:H:SiO_x coating for the human blood MNCs, suggesting a promising PACVD on Ti alloys for cardiovascular implants, including pumps for mechanical heart support systems.

Original language	English
Article number	112002
Journal	Materials Science and Engineering C
Volume	123
DOIs	https://doi.org/10.1016/j.msec.2021.112002
Publication status	Published - Apr 2021

Keywords

a-C:H:SiO coating
Corrosion resistance
Cytotoxicity
PACVD

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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Grenadyorov, A. S., Zhulkov, M. O., Solovyev, Oskomov, K. V., Semenov, V. A., Chernyavskiy, A. M., Sirota, D. A., Karmadonova, N. A., Malashchenko, V. V., Litvinova, L. S., Khaziakhmatova, O. G., Gazatova, N. D., & Khlusov, I. A. (2021). Surface characterization and biological assessment of corrosion-resistant a-C:H:SiO_x PACVD coating for Ti-6Al-4V alloy. Materials Science and Engineering C, 123, [112002]. https://doi.org/10.1016/j.msec.2021.112002

Surface characterization and biological assessment of corrosion-resistant a-C:H:SiO_x PACVD coating for Ti-6Al-4V alloy. / Grenadyorov, A. S.; Zhulkov, M. O.; Solovyev; Oskomov, K. V.; Semenov, V. A.; Chernyavskiy, A. M.; Sirota, D. A.; Karmadonova, N. A.; Malashchenko, V. V.; Litvinova, L. S.; Khaziakhmatova, O. G.; Gazatova, N. D.; Khlusov, I. A.

In: Materials Science and Engineering C, Vol. 123, 112002, 04.2021.

Research output: Contribution to journal › Article › peer-review

Grenadyorov, AS, Zhulkov, MO, Solovyev, Oskomov, KV, Semenov, VA, Chernyavskiy, AM, Sirota, DA, Karmadonova, NA, Malashchenko, VV, Litvinova, LS, Khaziakhmatova, OG, Gazatova, ND & Khlusov, IA 2021, 'Surface characterization and biological assessment of corrosion-resistant a-C:H:SiO_x PACVD coating for Ti-6Al-4V alloy', Materials Science and Engineering C, vol. 123, 112002. https://doi.org/10.1016/j.msec.2021.112002

Grenadyorov, A. S. ; Zhulkov, M. O. ; Solovyev ; Oskomov, K. V. ; Semenov, V. A. ; Chernyavskiy, A. M. ; Sirota, D. A. ; Karmadonova, N. A. ; Malashchenko, V. V. ; Litvinova, L. S. ; Khaziakhmatova, O. G. ; Gazatova, N. D. ; Khlusov, I. A. / Surface characterization and biological assessment of corrosion-resistant a-C:H:SiO_x PACVD coating for Ti-6Al-4V alloy. In: Materials Science and Engineering C. 2021 ; Vol. 123.

@article{93949aa9dd8c45b8a57ce28dd20c97ec,

title = "Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy",

abstract = "The paper focuses on the SiOx-doped amorphous hydrocarbon (a-C:H:SiOx) coating on the titanium (Ti-6Al-4V) alloy substrate obtained by plasma-assisted chemical vapor deposition (PACVD) in a mixture of argon gas and polyphenylmethylsiloxane vapor using a bipolar substrate bias. It is shown that the a-C:H:SiOx coating deposition results in the formation of a negative surface potential important for application of this coating for medical implants. The a-C:H:SiOx coatings improve the corrosion resistance of Ti alloy to 0.5 M NaCl solution and phosphate-buffered saline. In particular, the corrosion current density of the a-C:H:SiOx-coated sample in a 0.5 M NaCl solution at 22 °C decreases from 1∙10−8 to 1.7∙10−10 A/cm2, that reduces the corrosion rate from 9∙10−5 to 15∙10−7 mm/year. The a-C:H:SiOx coating facilitates the surface endothelization of an implant located in the thoracic aorta of a mini pig, and reduces the risk of thrombosis and implant failure. This effect can be explained by the ability of the a-C:H:SiOx coating ability to reduce in vitro a 24-hour secretion of pro-inflammatory interleukins (IL-6, IL-12(p70), IL-15, and IL-17) and cytokines (IFN-g and TNF-a) by blood mononuclear cells (MNCs) and elevates the concentration of anti-inflammatory interleukin IL-1Ra. In vitro analysis shows no cytotoxicity of the a-C:H:SiOx coating for the human blood MNCs, suggesting a promising PACVD on Ti alloys for cardiovascular implants, including pumps for mechanical heart support systems.",

keywords = "a-C:H:SiO coating, Corrosion resistance, Cytotoxicity, PACVD",

author = "Grenadyorov, {A. S.} and Zhulkov, {M. O.} and Solovyev and Oskomov, {K. V.} and Semenov, {V. A.} and Chernyavskiy, {A. M.} and Sirota, {D. A.} and Karmadonova, {N. A.} and Malashchenko, {V. V.} and Litvinova, {L. S.} and Khaziakhmatova, {O. G.} and Gazatova, {N. D.} and Khlusov, {I. A.}",

note = "Funding Information: The authors acknowledge the financial support from the Russian Science Foundation (Project No. 19-19-00186 ) and from the President of the Russian Federation (Grant MK-1234.2020.8 ) of corrosion resistance measurements. The experimental calculations were obtained in National Research Tomsk Polytechnic University (TPU) within the framework of the Competitiveness Enhancement Program of TPU. We would like to thank D. V. Sidelev, Associate Professor of TPU, for his help in conducting research into corrosion resistance. Publisher Copyright: {\textcopyright} 2021 Elsevier B.V. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = apr,

doi = "10.1016/j.msec.2021.112002",

language = "English",

volume = "123",

journal = "Materials Science and Engineering C",

issn = "0928-4931",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy

AU - Grenadyorov, A. S.

AU - Zhulkov, M. O.

AU - Solovyev, null

AU - Oskomov, K. V.

AU - Semenov, V. A.

AU - Chernyavskiy, A. M.

AU - Sirota, D. A.

AU - Karmadonova, N. A.

AU - Malashchenko, V. V.

AU - Litvinova, L. S.

AU - Khaziakhmatova, O. G.

AU - Gazatova, N. D.

AU - Khlusov, I. A.

N1 - Funding Information: The authors acknowledge the financial support from the Russian Science Foundation (Project No. 19-19-00186 ) and from the President of the Russian Federation (Grant MK-1234.2020.8 ) of corrosion resistance measurements. The experimental calculations were obtained in National Research Tomsk Polytechnic University (TPU) within the framework of the Competitiveness Enhancement Program of TPU. We would like to thank D. V. Sidelev, Associate Professor of TPU, for his help in conducting research into corrosion resistance. Publisher Copyright: © 2021 Elsevier B.V. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/4

Y1 - 2021/4

N2 - The paper focuses on the SiOx-doped amorphous hydrocarbon (a-C:H:SiOx) coating on the titanium (Ti-6Al-4V) alloy substrate obtained by plasma-assisted chemical vapor deposition (PACVD) in a mixture of argon gas and polyphenylmethylsiloxane vapor using a bipolar substrate bias. It is shown that the a-C:H:SiOx coating deposition results in the formation of a negative surface potential important for application of this coating for medical implants. The a-C:H:SiOx coatings improve the corrosion resistance of Ti alloy to 0.5 M NaCl solution and phosphate-buffered saline. In particular, the corrosion current density of the a-C:H:SiOx-coated sample in a 0.5 M NaCl solution at 22 °C decreases from 1∙10−8 to 1.7∙10−10 A/cm2, that reduces the corrosion rate from 9∙10−5 to 15∙10−7 mm/year. The a-C:H:SiOx coating facilitates the surface endothelization of an implant located in the thoracic aorta of a mini pig, and reduces the risk of thrombosis and implant failure. This effect can be explained by the ability of the a-C:H:SiOx coating ability to reduce in vitro a 24-hour secretion of pro-inflammatory interleukins (IL-6, IL-12(p70), IL-15, and IL-17) and cytokines (IFN-g and TNF-a) by blood mononuclear cells (MNCs) and elevates the concentration of anti-inflammatory interleukin IL-1Ra. In vitro analysis shows no cytotoxicity of the a-C:H:SiOx coating for the human blood MNCs, suggesting a promising PACVD on Ti alloys for cardiovascular implants, including pumps for mechanical heart support systems.

AB - The paper focuses on the SiOx-doped amorphous hydrocarbon (a-C:H:SiOx) coating on the titanium (Ti-6Al-4V) alloy substrate obtained by plasma-assisted chemical vapor deposition (PACVD) in a mixture of argon gas and polyphenylmethylsiloxane vapor using a bipolar substrate bias. It is shown that the a-C:H:SiOx coating deposition results in the formation of a negative surface potential important for application of this coating for medical implants. The a-C:H:SiOx coatings improve the corrosion resistance of Ti alloy to 0.5 M NaCl solution and phosphate-buffered saline. In particular, the corrosion current density of the a-C:H:SiOx-coated sample in a 0.5 M NaCl solution at 22 °C decreases from 1∙10−8 to 1.7∙10−10 A/cm2, that reduces the corrosion rate from 9∙10−5 to 15∙10−7 mm/year. The a-C:H:SiOx coating facilitates the surface endothelization of an implant located in the thoracic aorta of a mini pig, and reduces the risk of thrombosis and implant failure. This effect can be explained by the ability of the a-C:H:SiOx coating ability to reduce in vitro a 24-hour secretion of pro-inflammatory interleukins (IL-6, IL-12(p70), IL-15, and IL-17) and cytokines (IFN-g and TNF-a) by blood mononuclear cells (MNCs) and elevates the concentration of anti-inflammatory interleukin IL-1Ra. In vitro analysis shows no cytotoxicity of the a-C:H:SiOx coating for the human blood MNCs, suggesting a promising PACVD on Ti alloys for cardiovascular implants, including pumps for mechanical heart support systems.

KW - a-C:H:SiO coating

KW - Corrosion resistance

KW - Cytotoxicity

KW - PACVD

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DO - 10.1016/j.msec.2021.112002

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VL - 123

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

SN - 0928-4931

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ER -

Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy

Abstract

Keywords

ASJC Scopus subject areas

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Surface characterization and biological assessment of corrosion-resistant a-C:H:SiO_x PACVD coating for Ti-6Al-4V alloy