Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy

A. S. Grenadyorov, M. O. Zhulkov, Solovyev, K. V. Oskomov, V. A. Semenov, A. M. Chernyavskiy, D. A. Sirota, N. A. Karmadonova, V. V. Malashchenko, L. S. Litvinova, O. G. Khaziakhmatova, N. D. Gazatova, I. A. Khlusov

Research output: Contribution to journalArticlepeer-review

Abstract

The paper focuses on the SiOx-doped amorphous hydrocarbon (a-C:H:SiOx) coating on the titanium (Ti-6Al-4V) alloy substrate obtained by plasma-assisted chemical vapor deposition (PACVD) in a mixture of argon gas and polyphenylmethylsiloxane vapor using a bipolar substrate bias. It is shown that the a-C:H:SiOx coating deposition results in the formation of a negative surface potential important for application of this coating for medical implants. The a-C:H:SiOx coatings improve the corrosion resistance of Ti alloy to 0.5 M NaCl solution and phosphate-buffered saline. In particular, the corrosion current density of the a-C:H:SiOx-coated sample in a 0.5 M NaCl solution at 22 °C decreases from 1∙10−8 to 1.7∙10−10 A/cm2, that reduces the corrosion rate from 9∙10−5 to 15∙10−7 mm/year. The a-C:H:SiOx coating facilitates the surface endothelization of an implant located in the thoracic aorta of a mini pig, and reduces the risk of thrombosis and implant failure. This effect can be explained by the ability of the a-C:H:SiOx coating ability to reduce in vitro a 24-hour secretion of pro-inflammatory interleukins (IL-6, IL-12(p70), IL-15, and IL-17) and cytokines (IFN-g and TNF-a) by blood mononuclear cells (MNCs) and elevates the concentration of anti-inflammatory interleukin IL-1Ra. In vitro analysis shows no cytotoxicity of the a-C:H:SiOx coating for the human blood MNCs, suggesting a promising PACVD on Ti alloys for cardiovascular implants, including pumps for mechanical heart support systems.

Original languageEnglish
Article number112002
JournalMaterials Science and Engineering C
Volume123
DOIs
Publication statusPublished - Apr 2021

Keywords

  • a-C:H:SiO coating
  • Corrosion resistance
  • Cytotoxicity
  • PACVD

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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