Supramolecular Agents for Theranostics

S. M. Deyev, E. N. Lebedenko

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

This mini-review summarizes recent data obtained in the process of creation of a versatile module platform suitable for construction of supramolecular theranostic agents. As an example, we consider multifunctional hybrid agents for imaging and elimination of cancer cells. The use of an adapter protein system barnase:barstar for producing targeted multifunctional hybrid structures on the basis of highly specific peptides and mini-antibodies as addressing modules and recombinant proteins and/or nanoparticles of different nature (quantum dots, nanogold, magnetic nanoparticles, nanodiamonds, upconverting nanophosphores, polymer nanoparticles) as agents visualizing and damaging cancer cells is described. New perspectives for creation of selective and highly effective compounds for theranostics and personified medicine are contemplated.

Original languageEnglish
Pages (from-to)539-552
Number of pages14
JournalBioorganicheskaia khimiia
Volume41
Issue number5
Publication statusPublished - 1 Sep 2015

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ASJC Scopus subject areas

  • Medicine(all)

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