Abstract
This mini-review summarizes recent data obtained in the process of creation of a versatile module platform suitable for construction of supramolecular theranostic agents. As an example, we consider multifunctional hybrid agents for imaging and elimination of cancer cells. The use of an adapter protein system barnase:barstar for producing targeted multifunctional hybrid structures on the basis of highly specific peptides and mini-antibodies as addressing modules and recombinant proteins and/or nanoparticles of different nature (quantum dots, nanogold, magnetic nanoparticles, nanodiamonds, upconverting nanophosphores, polymer nanoparticles) as agents visualizing and damaging cancer cells is described. New perspectives for creation of selective and highly effective compounds for theranostics and personified medicine are contemplated.
| Original language | English |
|---|---|
| Pages (from-to) | 539-552 |
| Number of pages | 14 |
| Journal | Bioorganicheskaia khimiia |
| Volume | 41 |
| Issue number | 5 |
| Publication status | Published - 1 Sep 2015 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
Supramolecular Agents for Theranostics. / Deyev, S. M.; Lebedenko, E. N.
In: Bioorganicheskaia khimiia, Vol. 41, No. 5, 01.09.2015, p. 539-552.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Supramolecular Agents for Theranostics
AU - Deyev, S. M.
AU - Lebedenko, E. N.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - This mini-review summarizes recent data obtained in the process of creation of a versatile module platform suitable for construction of supramolecular theranostic agents. As an example, we consider multifunctional hybrid agents for imaging and elimination of cancer cells. The use of an adapter protein system barnase:barstar for producing targeted multifunctional hybrid structures on the basis of highly specific peptides and mini-antibodies as addressing modules and recombinant proteins and/or nanoparticles of different nature (quantum dots, nanogold, magnetic nanoparticles, nanodiamonds, upconverting nanophosphores, polymer nanoparticles) as agents visualizing and damaging cancer cells is described. New perspectives for creation of selective and highly effective compounds for theranostics and personified medicine are contemplated.
AB - This mini-review summarizes recent data obtained in the process of creation of a versatile module platform suitable for construction of supramolecular theranostic agents. As an example, we consider multifunctional hybrid agents for imaging and elimination of cancer cells. The use of an adapter protein system barnase:barstar for producing targeted multifunctional hybrid structures on the basis of highly specific peptides and mini-antibodies as addressing modules and recombinant proteins and/or nanoparticles of different nature (quantum dots, nanogold, magnetic nanoparticles, nanodiamonds, upconverting nanophosphores, polymer nanoparticles) as agents visualizing and damaging cancer cells is described. New perspectives for creation of selective and highly effective compounds for theranostics and personified medicine are contemplated.
UR - http://www.scopus.com/inward/record.url?scp=84965185278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84965185278&partnerID=8YFLogxK
M3 - Review article
VL - 41
SP - 539
EP - 552
JO - Bioorganicheskaya Khimiya
JF - Bioorganicheskaya Khimiya
SN - 0132-3423
IS - 5
ER -