Abstract
The influence of γ-irradiation and radiosensitizer AK-2123 on secretion of reactive oxygen species (ROS) of human neutrophils was studied, γ- irradiation (from 5 to 25 Gy) of the neutrophil suspension inhibited spontaneous chemiluminescence and activated phorbol-12-myristate-13-acetate (PMA)-stimulated chemiluminescence. The time of maximum PMA-stimulated chemiluminescence amplitude was decreased with the dose range from 2 to 25 Gy. The addition of radiosensitizer AK-2123 depressed the early PMA- stimulated chemiluminescence response to γ-irradiation. The obtained results suggest that this effect is connected with influence of AK-2123 on ion canals of neutrophils and may prevent the radiation-induced damage of blood cells.
Original language | English |
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Pages (from-to) | 453-456 |
Number of pages | 4 |
Journal | Cancer Biotherapy and Radiopharmaceuticals |
Volume | 13 |
Issue number | 6 |
Publication status | Published - 1998 |
Externally published | Yes |
Keywords
- γ-irradiation
- Neutrophils
- Radiosensitizer
- Reactive oxygen species
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Pharmacology