Abstract
The influence of γ-irradiation and radiosensitizer AK-2123 on secretion of reactive oxygen species (ROS) of human neutrophils was studied, γ- irradiation (from 5 to 25 Gy) of the neutrophil suspension inhibited spontaneous chemiluminescence and activated phorbol-12-myristate-13-acetate (PMA)-stimulated chemiluminescence. The time of maximum PMA-stimulated chemiluminescence amplitude was decreased with the dose range from 2 to 25 Gy. The addition of radiosensitizer AK-2123 depressed the early PMA- stimulated chemiluminescence response to γ-irradiation. The obtained results suggest that this effect is connected with influence of AK-2123 on ion canals of neutrophils and may prevent the radiation-induced damage of blood cells.
| Original language | English |
|---|---|
| Pages (from-to) | 453-456 |
| Number of pages | 4 |
| Journal | Cancer Biotherapy and Radiopharmaceuticals |
| Volume | 13 |
| Issue number | 6 |
| Publication status | Published - 1998 |
| Externally published | Yes |
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Keywords
- γ-irradiation
- Neutrophils
- Radiosensitizer
- Reactive oxygen species
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Pharmacology
Cite this
Suppression by radiosensitizer AK-2123 of early phorbol myristate acetate-stimulated chemiluminescence response of human neutrophils induced by gamma-irradiation (short communication). / Schepetkin, Igor.
In: Cancer Biotherapy and Radiopharmaceuticals, Vol. 13, No. 6, 1998, p. 453-456.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppression by radiosensitizer AK-2123 of early phorbol myristate acetate-stimulated chemiluminescence response of human neutrophils induced by gamma-irradiation (short communication)
AU - Schepetkin, Igor
PY - 1998
Y1 - 1998
N2 - The influence of γ-irradiation and radiosensitizer AK-2123 on secretion of reactive oxygen species (ROS) of human neutrophils was studied, γ- irradiation (from 5 to 25 Gy) of the neutrophil suspension inhibited spontaneous chemiluminescence and activated phorbol-12-myristate-13-acetate (PMA)-stimulated chemiluminescence. The time of maximum PMA-stimulated chemiluminescence amplitude was decreased with the dose range from 2 to 25 Gy. The addition of radiosensitizer AK-2123 depressed the early PMA- stimulated chemiluminescence response to γ-irradiation. The obtained results suggest that this effect is connected with influence of AK-2123 on ion canals of neutrophils and may prevent the radiation-induced damage of blood cells.
AB - The influence of γ-irradiation and radiosensitizer AK-2123 on secretion of reactive oxygen species (ROS) of human neutrophils was studied, γ- irradiation (from 5 to 25 Gy) of the neutrophil suspension inhibited spontaneous chemiluminescence and activated phorbol-12-myristate-13-acetate (PMA)-stimulated chemiluminescence. The time of maximum PMA-stimulated chemiluminescence amplitude was decreased with the dose range from 2 to 25 Gy. The addition of radiosensitizer AK-2123 depressed the early PMA- stimulated chemiluminescence response to γ-irradiation. The obtained results suggest that this effect is connected with influence of AK-2123 on ion canals of neutrophils and may prevent the radiation-induced damage of blood cells.
KW - γ-irradiation
KW - Neutrophils
KW - Radiosensitizer
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=0032417117&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032417117&partnerID=8YFLogxK
M3 - Article
C2 - 10851438
AN - SCOPUS:0032417117
VL - 13
SP - 453
EP - 456
JO - Cancer Biotherapy and Radiopharmaceuticals
JF - Cancer Biotherapy and Radiopharmaceuticals
SN - 1084-9785
IS - 6
ER -