TY - JOUR
T1 - 114mIn, a candidate for radionuclide therapy
T2 - Low-energy cyclotron production and labeling of DTPA-D-Phe-octreotide
AU - Tolmachev, Vladimir
AU - Bernhardt, Peter
AU - Forssell-Aronsson, Eva
AU - Lundqvist, Hans
N1 - Funding Information:
We thank the personnel at Uppsala University PET Center and The Svedberg Laboratory for technical assistance, and Mr. Tom Bäck, Göteborg, for excellent assistance with the animal study. Financial support was given by The Swedish Cancer Society (project numbers 3427, 3978). 30
Copyright:
Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.
PY - 2000/2
Y1 - 2000/2
N2 - A method for production of carrier-free 114mIn (half-life 49.5 days), which is a potential radionuclide for radionuclide therapy of slowly growing tumors, is presented. A target consisting of five enriched cadmium (114Cd) foils, each 50 μm thick, was irradiated by protons (from 12.6-6.5 MeV) giving a target yield of 0.8 MBq/μAh. A simple and cost-efficient thermal diffusion method was used for the separation. The irradiated target foils were heated for 2 h at 306°C and then etched in 0.05 M HCl. The obtained cadmium/indium solution was purified using a cation ion-exchange resin (AG 1 x 8, Bio-Rad Laboratories, Hercules, CA USA). An overall yield of approximately 60% was obtained, whereas the loss of the target material was <1% per separation cycle. The 114mIn production gave 114mIn with high specific radioactivity and was successfully used to label diethylenetriamine pentaacetic acid (DTPA)-D-Phe-octreotide. Furthermore, no difference in biodistribution between [114mIn]- and [111In]-DTPA-D-Phe1-octreotide in tumor-bearing nude mice was seen. The high radionuclide uptake in the tumors indicates a good receptor binding of the labeled octreotide. Copyright (C) 2000 Elsevier Science Inc.
AB - A method for production of carrier-free 114mIn (half-life 49.5 days), which is a potential radionuclide for radionuclide therapy of slowly growing tumors, is presented. A target consisting of five enriched cadmium (114Cd) foils, each 50 μm thick, was irradiated by protons (from 12.6-6.5 MeV) giving a target yield of 0.8 MBq/μAh. A simple and cost-efficient thermal diffusion method was used for the separation. The irradiated target foils were heated for 2 h at 306°C and then etched in 0.05 M HCl. The obtained cadmium/indium solution was purified using a cation ion-exchange resin (AG 1 x 8, Bio-Rad Laboratories, Hercules, CA USA). An overall yield of approximately 60% was obtained, whereas the loss of the target material was <1% per separation cycle. The 114mIn production gave 114mIn with high specific radioactivity and was successfully used to label diethylenetriamine pentaacetic acid (DTPA)-D-Phe-octreotide. Furthermore, no difference in biodistribution between [114mIn]- and [111In]-DTPA-D-Phe1-octreotide in tumor-bearing nude mice was seen. The high radionuclide uptake in the tumors indicates a good receptor binding of the labeled octreotide. Copyright (C) 2000 Elsevier Science Inc.
KW - In
KW - [In]DTPA-D-Phe-octreotide
KW - Animal study
KW - Labeling
KW - Production
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U2 - 10.1016/S0969-8051(99)00096-7
DO - 10.1016/S0969-8051(99)00096-7
M3 - Article
C2 - 10773548
AN - SCOPUS:0033625205
VL - 27
SP - 183
EP - 188
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
SN - 0969-8051
IS - 2
ER -