114mIn, a candidate for radionuclide therapy: Low-energy cyclotron production and labeling of DTPA-D-Phe-octreotide

Vladimir Tolmachev, Peter Bernhardt, Eva Forssell-Aronsson, Hans Lundqvist

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

A method for production of carrier-free 114mIn (half-life 49.5 days), which is a potential radionuclide for radionuclide therapy of slowly growing tumors, is presented. A target consisting of five enriched cadmium (114Cd) foils, each 50 μm thick, was irradiated by protons (from 12.6-6.5 MeV) giving a target yield of 0.8 MBq/μAh. A simple and cost-efficient thermal diffusion method was used for the separation. The irradiated target foils were heated for 2 h at 306°C and then etched in 0.05 M HCl. The obtained cadmium/indium solution was purified using a cation ion-exchange resin (AG 1 x 8, Bio-Rad Laboratories, Hercules, CA USA). An overall yield of approximately 60% was obtained, whereas the loss of the target material was <1% per separation cycle. The 114mIn production gave 114mIn with high specific radioactivity and was successfully used to label diethylenetriamine pentaacetic acid (DTPA)-D-Phe-octreotide. Furthermore, no difference in biodistribution between [114mIn]- and [111In]-DTPA-D-Phe1-octreotide in tumor-bearing nude mice was seen. The high radionuclide uptake in the tumors indicates a good receptor binding of the labeled octreotide. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalNuclear Medicine and Biology
Volume27
Issue number2
DOIs
Publication statusPublished - Feb 2000
Externally publishedYes

Keywords

  • In
  • [In]DTPA-D-Phe-octreotide
  • Animal study
  • Labeling
  • Production

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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