Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3

Abstract

We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, ^99mTc-Al₂O₃. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.

Original language	English
Pages (from-to)	371-373
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	161
Issue number	3
DOIs	https://doi.org/10.1007/s10517-016-3416-0
Publication status	Published - 1 Jul 2016

Keywords

acute toxicity
cumulation
preclinical trials
radiopharmaceutical
subchronic toxicity

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/s10517-016-3416-0

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Varlamova, N. V., Churin, A. A., Fomina, T. I., Ermolaeva, L. A., Vetoshkina, T. V., Dubskaya, T. Y., Lamzina, T. Y., Fedorova, E. P., Neupokoeva, O. V., Skuridin, V. S., Nesterov, E. A., Larionova, L. A., & Chernov, V. I. (2016). Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, ^99mTc-Al₂O₃. Bulletin of Experimental Biology and Medicine, 161(3), 371-373. https://doi.org/10.1007/s10517-016-3416-0

Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, ^99mTc-Al₂O₃. / Varlamova, N. V.; Churin, A. A.; Fomina, T. I.; Ermolaeva, L. A.; Vetoshkina, T. V.; Dubskaya, T. Yu; Lamzina, T. Yu; Fedorova, E. P.; Neupokoeva, O. V.; Skuridin, V. S.; Nesterov, E. A.; Larionova, L. A.; Chernov, V. I.

In: Bulletin of Experimental Biology and Medicine, Vol. 161, No. 3, 01.07.2016, p. 371-373.

Research output: Contribution to journal › Article

Varlamova, NV, Churin, AA, Fomina, TI, Ermolaeva, LA, Vetoshkina, TV, Dubskaya, TY, Lamzina, TY, Fedorova, EP, Neupokoeva, OV, Skuridin, VS , Nesterov, EA, Larionova, LA & Chernov, VI 2016, 'Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, ^99mTc-Al₂O₃', Bulletin of Experimental Biology and Medicine, vol. 161, no. 3, pp. 371-373. https://doi.org/10.1007/s10517-016-3416-0

Varlamova, N. V. ; Churin, A. A. ; Fomina, T. I. ; Ermolaeva, L. A. ; Vetoshkina, T. V. ; Dubskaya, T. Yu ; Lamzina, T. Yu ; Fedorova, E. P. ; Neupokoeva, O. V. ; Skuridin, V. S. ; Nesterov, E. A. ; Larionova, L. A. ; Chernov, V. I. / Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, ^99mTc-Al₂O₃. In: Bulletin of Experimental Biology and Medicine. 2016 ; Vol. 161, No. 3. pp. 371-373.

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abstract = "We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.",

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AU - Ermolaeva, L. A.

AU - Vetoshkina, T. V.

AU - Dubskaya, T. Yu

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AU - Fedorova, E. P.

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AU - Skuridin, V. S.

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