Abstract
We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.
| Original language | English |
|---|---|
| Pages (from-to) | 371-373 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 161 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Jul 2016 |
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Keywords
- acute toxicity
- cumulation
- preclinical trials
- radiopharmaceutical
- subchronic toxicity
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3. / Varlamova, N. V.; Churin, A. A.; Fomina, T. I.; Ermolaeva, L. A.; Vetoshkina, T. V.; Dubskaya, T. Yu; Lamzina, T. Yu; Fedorova, E. P.; Neupokoeva, O. V.; Skuridin, V. S.; Nesterov, E. A.; Larionova, L. A.; Chernov, V. I.
In: Bulletin of Experimental Biology and Medicine, Vol. 161, No. 3, 01.07.2016, p. 371-373.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3
AU - Varlamova, N. V.
AU - Churin, A. A.
AU - Fomina, T. I.
AU - Ermolaeva, L. A.
AU - Vetoshkina, T. V.
AU - Dubskaya, T. Yu
AU - Lamzina, T. Yu
AU - Fedorova, E. P.
AU - Neupokoeva, O. V.
AU - Skuridin, V. S.
AU - Nesterov, E. A.
AU - Larionova, L. A.
AU - Chernov, V. I.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.
AB - We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.
KW - acute toxicity
KW - cumulation
KW - preclinical trials
KW - radiopharmaceutical
KW - subchronic toxicity
UR - http://www.scopus.com/inward/record.url?scp=84981263320&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84981263320&partnerID=8YFLogxK
U2 - 10.1007/s10517-016-3416-0
DO - 10.1007/s10517-016-3416-0
M3 - Article
VL - 161
SP - 371
EP - 373
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 3
ER -