Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3

N. V. Varlamova, A. A. Churin, T. I. Fomina, L. A. Ermolaeva, T. V. Vetoshkina, T. Yu Dubskaya, T. Yu Lamzina, E. P. Fedorova, O. V. Neupokoeva, V. S. Skuridin, E. A. Nesterov, L. A. Larionova, V. I. Chernov

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Abstract

We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.

Original languageEnglish
Pages (from-to)371-373
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume161
Issue number3
DOIs
Publication statusPublished - 1 Jul 2016

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Keywords

  • acute toxicity
  • cumulation
  • preclinical trials
  • radiopharmaceutical
  • subchronic toxicity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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