Studying acute toxicity of new radiopharmaceutical 99MTC-AL2O3 nanocolloids for oncological diagnostics

N. V. Varlamova, V. S. Skuridin, E. A. Nesterov, V. I. Chernov, A. A. Titskaya

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The acute toxicity of a new drug based on nanocolloidal gamma alumina labeled with technetium-99m (99mTc) has been studied on 80 rats (40 females and 40 males) and 80 mice (40 females and 40 males) with intraperitoneal and subcutaneous drug administration. A single administration of the pharmacological agent was followed by observation of the survival of animals for 14 days with determining tolerable, toxic, and lethal doses for intraperitoneal and subcutaneous administration according to the Litchfield - Wilcoxon method, establishing the causes of animal death within 14 days of observation, and studying the drug influence on the general condition and some functional and morphological indices. Based on the established boundaries of toxicity and the classification of toxicity, the 99mTc-Al2O3 nanocolloids can be classified into conditionally moderately toxic substances. The actual values of LD50 of the radiopharmaceutical fall in the range of large doses. The safety factor for the drug studied significantly exceeds the minimum permissible value of 100.

Original languageEnglish
Pages (from-to)26-29
Number of pages4
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume78
Issue number6
Publication statusPublished - 1 Jan 2015

Fingerprint

Radiopharmaceuticals
Toxicity
Poisons
Pharmaceutical Preparations
Animals
Observation
Aluminum Oxide
Lethal Dose 50
Safety factor
Technetium
Rats
Cause of Death
Pharmacology
Safety

Keywords

  • Acute toxicity
  • Gamma-alumina
  • Lymph node
  • Mice
  • Nanocolloid
  • Radiopharmaceutical
  • Rats

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Studying acute toxicity of new radiopharmaceutical 99MTC-AL2O3 nanocolloids for oncological diagnostics. / Varlamova, N. V.; Skuridin, V. S.; Nesterov, E. A.; Chernov, V. I.; Titskaya, A. A.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 78, No. 6, 01.01.2015, p. 26-29.

Research output: Contribution to journalArticle

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