Abstract
The aim of the investigation was to assess the allergizing properties of a new nanocolloidal preparation based on aluminum gamma-oxide labeled by technetium-99m for scintigraphic and intraoperative detection of sentinel lymphatic nodes in experiment. Materials and Methods. A series of experiments was performed on 80 guinea pigs, 30 Balb/c mice, 40 CBA/CaLac mice and 70 outbred mice of both genders. To study allergenicity various doses of preparation were administered subcutaneously, intramuscularly, intravenously, intradermally as a single injection or by a course. Allergizing properties of the radiopharmaceutical were investigated according to the “Guidelines on the assessment of allergizing properties of drugs”Results. Administration of Nanocolloid,99mTc‒Al2O3 radiopharmaceutical did not result in the intensification of anaphylaxis systemic reaction in the animals of the examined groups relative to the control. A single injection did not cause inflammatory reaction to Concanavalin A in the examined animals. When guinea pigs were immunized by the preparation, no delayed allergic reaction was revealed. Studying sensitizing effect of the preparation by 20 skin applications no redness or edema of the skin at the site of application was observed. Conclusion. Nanocolloid,99mTc‒Al2O3 radiopharmaceutical in the studied doses and under the selected experimental conditions does not possess allergizing properties.
| Original language | English |
|---|---|
| Pages (from-to) | 72-76 |
| Number of pages | 5 |
| Journal | Sovremennye Tehnologii v Medicine |
| Volume | 7 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Jan 2015 |
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Keywords
- Allergizing properties
- Nanocolloid
- Radiopharmaceuticals
- Sentinel lymphatic node
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Study of the allergizing properties of nanocolloid,99mTc–Al2O3 radiopharmaceutical in experiment. / Varlamova, Natalia Valerievna; Stasyuk, Elena Sergeevna; Titskaya, A. A.; Sinilkin, Ivan Gennadievich; Larionova, L. A.; Sherstoboyev, E. Y.; Trofimova, E. S.; Ligacheva, A. A.; Skuridin, V. S.
In: Sovremennye Tehnologii v Medicine, Vol. 7, No. 4, 01.01.2015, p. 72-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Study of the allergizing properties of nanocolloid,99mTc–Al2O3 radiopharmaceutical in experiment
AU - Varlamova, Natalia Valerievna
AU - Stasyuk, Elena Sergeevna
AU - Titskaya, A. A.
AU - Sinilkin, Ivan Gennadievich
AU - Larionova, L. A.
AU - Sherstoboyev, E. Y.
AU - Trofimova, E. S.
AU - Ligacheva, A. A.
AU - Skuridin, V. S.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - The aim of the investigation was to assess the allergizing properties of a new nanocolloidal preparation based on aluminum gamma-oxide labeled by technetium-99m for scintigraphic and intraoperative detection of sentinel lymphatic nodes in experiment. Materials and Methods. A series of experiments was performed on 80 guinea pigs, 30 Balb/c mice, 40 CBA/CaLac mice and 70 outbred mice of both genders. To study allergenicity various doses of preparation were administered subcutaneously, intramuscularly, intravenously, intradermally as a single injection or by a course. Allergizing properties of the radiopharmaceutical were investigated according to the “Guidelines on the assessment of allergizing properties of drugs”Results. Administration of Nanocolloid,99mTc‒Al2O3 radiopharmaceutical did not result in the intensification of anaphylaxis systemic reaction in the animals of the examined groups relative to the control. A single injection did not cause inflammatory reaction to Concanavalin A in the examined animals. When guinea pigs were immunized by the preparation, no delayed allergic reaction was revealed. Studying sensitizing effect of the preparation by 20 skin applications no redness or edema of the skin at the site of application was observed. Conclusion. Nanocolloid,99mTc‒Al2O3 radiopharmaceutical in the studied doses and under the selected experimental conditions does not possess allergizing properties.
AB - The aim of the investigation was to assess the allergizing properties of a new nanocolloidal preparation based on aluminum gamma-oxide labeled by technetium-99m for scintigraphic and intraoperative detection of sentinel lymphatic nodes in experiment. Materials and Methods. A series of experiments was performed on 80 guinea pigs, 30 Balb/c mice, 40 CBA/CaLac mice and 70 outbred mice of both genders. To study allergenicity various doses of preparation were administered subcutaneously, intramuscularly, intravenously, intradermally as a single injection or by a course. Allergizing properties of the radiopharmaceutical were investigated according to the “Guidelines on the assessment of allergizing properties of drugs”Results. Administration of Nanocolloid,99mTc‒Al2O3 radiopharmaceutical did not result in the intensification of anaphylaxis systemic reaction in the animals of the examined groups relative to the control. A single injection did not cause inflammatory reaction to Concanavalin A in the examined animals. When guinea pigs were immunized by the preparation, no delayed allergic reaction was revealed. Studying sensitizing effect of the preparation by 20 skin applications no redness or edema of the skin at the site of application was observed. Conclusion. Nanocolloid,99mTc‒Al2O3 radiopharmaceutical in the studied doses and under the selected experimental conditions does not possess allergizing properties.
KW - Allergizing properties
KW - Nanocolloid
KW - Radiopharmaceuticals
KW - Sentinel lymphatic node
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UR - http://www.scopus.com/inward/citedby.url?scp=84952779493&partnerID=8YFLogxK
U2 - 10.17691/stm2015.7.4.09
DO - 10.17691/stm2015.7.4.09
M3 - Article
VL - 7
SP - 72
EP - 76
JO - Sovremennye Tehnologii v Medicine
JF - Sovremennye Tehnologii v Medicine
SN - 2076-4243
IS - 4
ER -