Study of Fibronectin Type III-Like Domains Role in Activation of gp130 Receptor

A. V. Stepanov, A. S. Rybinets, M. A. Dronina, S. M. Deev

Research output: Contribution to journalArticlepeer-review

Abstract

Chimeric gp130 receptors were produced to study the role of three fibronectin type III-like domains in activation of gp130 receptor machinery. The ligand-induced dimerization of gp130 was sufficient to trigger STAT3 signaling pathway. These findings can be used as the basis in designing novel therapeutic gp130 inhibitors.

Original languageEnglish
Pages (from-to)72-74
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume161
Issue number1
DOIs
Publication statusPublished - 1 May 2016
Externally publishedYes

Keywords

  • chimeric receptor
  • fibronectin type III-like domains
  • gp130
  • gp130 dimerization
  • IL-6 receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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