Chimeric gp130 receptors were produced to study the role of three fibronectin type III-like domains in activation of gp130 receptor machinery. The ligand-induced dimerization of gp130 was sufficient to trigger STAT3 signaling pathway. These findings can be used as the basis in designing novel therapeutic gp130 inhibitors.
- chimeric receptor
- fibronectin type III-like domains
- gp130 dimerization
- IL-6 receptor
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)