Study of adsorption doxorubicin by iron-carbon composite powders

Tatiana Yurmazova, Victoria Ivanova, Mikhail Buldakov, Sergey Galanov

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Method of electric-spark dispersion of iron particles in water, ethyl alcohol, phosphoric acid solution and hexane has been applied to produce composite magnetic nanosized powders. Their phase composition, dispersity, magnetic susceptibility, and adsorption-desorption properties towards anti-tumor remedy doxorubicin have been studied. It is shown that the obtained powder in hexane has the highest adsorption capacity towards doxorubicin. This is probably the evidence of surface compound formation. It is durable adsorption complex, which is formed from carbonyl and amine groups of organic cations and vacant orbitals of iron d-sublevel. The powder, obtained in hexane, can be dissolved in human blood plasma and amino acid solutions: possible time of iron elimination from human organism is smaller than 10 days. It is shown possibility of application iron-carbon sorbent is in quality of magnetic carrier doxorubicin to cancer cells.

Original languageEnglish
Title of host publicationKey Engineering Materials
PublisherTrans Tech Publications Ltd
Pages331-337
Number of pages7
Volume683
ISBN (Print)9783038357292
DOIs
Publication statusPublished - 2016
Event12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015 - Tomsk, Russian Federation
Duration: 21 Apr 201524 Apr 2015

Publication series

NameKey Engineering Materials
Volume683
ISSN (Print)10139826

Other

Other12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015
CountryRussian Federation
CityTomsk
Period21.4.1524.4.15

Keywords

  • Adsorption
  • Doxorubicin
  • Iron nanoparticles
  • Iron-carbon sorbent
  • Pulse electric discharge
  • Sorption isotherms
  • Zeta-potential

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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