Studies of the Effects of Antibiotics on the Microflora of the Gastrointestinal Tract by Fluorimetry

E. V. Bulycheva, E. I. Korotkova, E. V. Timofeeva

Research output: Contribution to journalArticle


An approach to identifying the effects of different groups of antibiotics (tetracyclines, penicillins, cephalosporins) on the vital activity of lactobacilli by fluorimetry is described. The method is based on measurement of the fluorescence intensity of the intracellular metabolite nicotinamide adenine dinucleotide, reduced form (NADH). Different classes of antibiotics were found to have different effects on lactobacilli. Amoxycillin produced no microbial death, while tetracycline and cephazolin had different levels of fatal effects on lactobacilli.

Original languageEnglish
Pages (from-to)262-264
Number of pages3
JournalPharmaceutical Chemistry Journal
Issue number4
Publication statusPublished - 1 Aug 2016



  • antimicrobial activity
  • intracellular metabolite
  • lactobacilli
  • luminescence analysis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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