Studies of the Effects of Antibiotics on the Microflora of the Gastrointestinal Tract by Fluorimetry

E. V. Bulycheva, E. I. Korotkova, E. V. Timofeeva

Research output: Contribution to journalArticle

Abstract

An approach to identifying the effects of different groups of antibiotics (tetracyclines, penicillins, cephalosporins) on the vital activity of lactobacilli by fluorimetry is described. The method is based on measurement of the fluorescence intensity of the intracellular metabolite nicotinamide adenine dinucleotide, reduced form (NADH). Different classes of antibiotics were found to have different effects on lactobacilli. Amoxycillin produced no microbial death, while tetracycline and cephazolin had different levels of fatal effects on lactobacilli.

Original languageEnglish
Pages (from-to)262-264
Number of pages3
JournalPharmaceutical Chemistry Journal
Volume50
Issue number4
DOIs
Publication statusPublished - 1 Aug 2016

Keywords

  • antimicrobial activity
  • intracellular metabolite
  • lactobacilli
  • luminescence analysis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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