Stimulation of σ1 receptors alleviates reperfusion-induced myocardial stunning

L. N. Maslov, Yu B. Lishmanov

Research output: Contribution to journalArticle

Abstract

In vivo or in vitro administration of a σ1 receptor agonist d-SKF 10.047 (1 mg/kg intravenously or 10 mg/l in vitro) promoted an increase in the resistance of isolated perfused rat heart to ischemia/reperfusion injury. Both in vivo and in vitro stimulation of σ receptors prevents the development of reperfusion contracture and creatine kinase release and increases the developed pressure, double product, +dP/dt, and -dP/dt in the left ventricle. Activation of a receptors has no significant effect on the occurrence of reperfusion arrhythmias ex vivo. Stimulation of cardiac sigma receptors is proposed to prevent myocardial stunning.

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalBiology Bulletin
Volume31
Issue number2
DOIs
Publication statusPublished - 1 Mar 2004

Fingerprint

myocardial stunning
sigma Receptors
Myocardial Stunning
Creatine Kinase
Reperfusion
Rats
Chemical activation
receptors
Contracture
contracture
Reperfusion Injury
Heart Ventricles
Cardiac Arrhythmias
arrhythmia
creatine kinase
ischemia
agonists
Pressure
heart
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Stimulation of σ1 receptors alleviates reperfusion-induced myocardial stunning. / Maslov, L. N.; Lishmanov, Yu B.

In: Biology Bulletin, Vol. 31, No. 2, 01.03.2004, p. 168-174.

Research output: Contribution to journalArticle

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