In vivo or in vitro administration of a σ1 receptor agonist d-SKF 10.047 (1 mg/kg intravenously or 10 mg/l in vitro) promoted an increase in the resistance of isolated perfused rat heart to ischemia/reperfusion injury. Both in vivo and in vitro stimulation of σ receptors prevents the development of reperfusion contracture and creatine kinase release and increases the developed pressure, double product, +dP/dt, and -dP/dt in the left ventricle. Activation of a receptors has no significant effect on the occurrence of reperfusion arrhythmias ex vivo. Stimulation of cardiac sigma receptors is proposed to prevent myocardial stunning.
|Number of pages||7|
|Publication status||Published - 1 Mar 2004|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)