Stimulation of σ1 receptors alleviates reperfusion-induced myocardial stunning

L. N. Maslov, Yu B. Lishmanov

Research output: Contribution to journalArticle

Abstract

In vivo or in vitro administration of a σ1 receptor agonist d-SKF 10.047 (1 mg/kg intravenously or 10 mg/l in vitro) promoted an increase in the resistance of isolated perfused rat heart to ischemia/reperfusion injury. Both in vivo and in vitro stimulation of σ receptors prevents the development of reperfusion contracture and creatine kinase release and increases the developed pressure, double product, +dP/dt, and -dP/dt in the left ventricle. Activation of a receptors has no significant effect on the occurrence of reperfusion arrhythmias ex vivo. Stimulation of cardiac sigma receptors is proposed to prevent myocardial stunning.

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalBiology Bulletin
Volume31
Issue number2
DOIs
Publication statusPublished - 1 Mar 2004

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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