Abstract
It was found that intravenous administration of σ-receptor agonists (+)-SKF 10047 and (+)-bremazocine or κ2-agonist (-)-bremazocine resulted in increased tolerance of isolated perfused rat heart to ischemic and reperfusion damages. Both κ2- and σ-receptor stimulation prevented the development of reperfusion contracture, increased left ventricular developed pressure, the double product, +dP/dt and -dP/dt. Only σ-receptor agonists (d-SKF 10047 and d-bremazocine) prevented arrhythmias caused by reoxygenation. By contrast, only κ2-agonist (-)-bremazocine prevented development of reperfusion no-reflow phenomenon in vitro and increased tolerance of the heart to arrhythmogenic action of epinephrine in vivo. Of the three compounds tested, only (+)-SKF 10047 abolished reoxygenation cell membrane injuries. Thus activation of cardiac σ- and κ2-receptors might be useful for prevention of myocardial stunning. Stimulation of σ- and κ2-receptors can be used for protection of the heart against arrhythmogenic action of reperfusion and adrenergic agents, respectively. κ2-receptor agonists can be used for prevention of no-reflow phenomenon and σ-receptor agonist (+)-SKF 10047 -for protection against cardiac sarcolemma injury.
| Original language | English |
|---|---|
| Pages (from-to) | 70-76 |
| Number of pages | 7 |
| Journal | Kardiologiya |
| Volume | 41 |
| Issue number | 1 |
| Publication status | Published - 2001 |
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Keywords
- Kappa
- Myocardial reperfusion
- Opioid receptors
- Sigma
- Stunning
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Stimulation of κ2- And σ-Receptors as a Possible Approach to Prevention of Myocardial Dysfunction Caused by Reperfusion. / Lishmanov, Yu B.; Maslov, L. N.; Tam, S. W.
In: Kardiologiya, Vol. 41, No. 1, 2001, p. 70-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stimulation of κ2- And σ-Receptors as a Possible Approach to Prevention of Myocardial Dysfunction Caused by Reperfusion
AU - Lishmanov, Yu B.
AU - Maslov, L. N.
AU - Tam, S. W.
PY - 2001
Y1 - 2001
N2 - It was found that intravenous administration of σ-receptor agonists (+)-SKF 10047 and (+)-bremazocine or κ2-agonist (-)-bremazocine resulted in increased tolerance of isolated perfused rat heart to ischemic and reperfusion damages. Both κ2- and σ-receptor stimulation prevented the development of reperfusion contracture, increased left ventricular developed pressure, the double product, +dP/dt and -dP/dt. Only σ-receptor agonists (d-SKF 10047 and d-bremazocine) prevented arrhythmias caused by reoxygenation. By contrast, only κ2-agonist (-)-bremazocine prevented development of reperfusion no-reflow phenomenon in vitro and increased tolerance of the heart to arrhythmogenic action of epinephrine in vivo. Of the three compounds tested, only (+)-SKF 10047 abolished reoxygenation cell membrane injuries. Thus activation of cardiac σ- and κ2-receptors might be useful for prevention of myocardial stunning. Stimulation of σ- and κ2-receptors can be used for protection of the heart against arrhythmogenic action of reperfusion and adrenergic agents, respectively. κ2-receptor agonists can be used for prevention of no-reflow phenomenon and σ-receptor agonist (+)-SKF 10047 -for protection against cardiac sarcolemma injury.
AB - It was found that intravenous administration of σ-receptor agonists (+)-SKF 10047 and (+)-bremazocine or κ2-agonist (-)-bremazocine resulted in increased tolerance of isolated perfused rat heart to ischemic and reperfusion damages. Both κ2- and σ-receptor stimulation prevented the development of reperfusion contracture, increased left ventricular developed pressure, the double product, +dP/dt and -dP/dt. Only σ-receptor agonists (d-SKF 10047 and d-bremazocine) prevented arrhythmias caused by reoxygenation. By contrast, only κ2-agonist (-)-bremazocine prevented development of reperfusion no-reflow phenomenon in vitro and increased tolerance of the heart to arrhythmogenic action of epinephrine in vivo. Of the three compounds tested, only (+)-SKF 10047 abolished reoxygenation cell membrane injuries. Thus activation of cardiac σ- and κ2-receptors might be useful for prevention of myocardial stunning. Stimulation of σ- and κ2-receptors can be used for protection of the heart against arrhythmogenic action of reperfusion and adrenergic agents, respectively. κ2-receptor agonists can be used for prevention of no-reflow phenomenon and σ-receptor agonist (+)-SKF 10047 -for protection against cardiac sarcolemma injury.
KW - Kappa
KW - Myocardial reperfusion
KW - Opioid receptors
KW - Sigma
KW - Stunning
UR - http://www.scopus.com/inward/record.url?scp=0346507507&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0346507507&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0346507507
VL - 41
SP - 70
EP - 76
JO - Kardiologiya
JF - Kardiologiya
SN - 0022-9040
IS - 1
ER -