Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant

Ioannis G. Theodorou, Danielle Botelho, Stephan Schwander, Junfeng Zhang, Kian Fan Chung, Teresa D. Tetley, Milo S P Shaffer, Andrew Gow, Mary P. Ryan, Alexandra E. Porter

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The increase of production volumes of silver nanowires (AgNWs) and of consumer products incorporating them may lead to increased health risks from occupational and public exposures. There is currently limited information about the putative toxicity of AgNWs upon inhalation and incomplete understanding of the properties that control their bioreactivity. The lung lining fluid (LLF), which contains phospholipids and surfactant proteins, represents a first contact site with the respiratory system. In this work, the impact of dipalmitoylphosphatidylcholine (DPPC), Curosurf, and murine LLF on the stability of AgNWs was examined. Both the phospholipid and protein components of the LLF modified the dissolution kinetics of AgNWs, due to the formation of a lipid corona or aggregation of the AgNWs. Moreover, the hydrophilic proteins, but neither the hydrophobic surfactant proteins nor the phospholipids, induced agglomeration of the AgNWs. Finally, the generation of a secondary population of nanosilver was observed and attributed to the reduction of Ag+ ions by the surface capping of the AgNWs. Our findings highlight that combinations of spatially resolved dynamic and static techniques are required to develop a holistic understanding of which parameters govern AgNW behavior at the point of exposure and to accurately predict their risks on human health and the environment. (Figure Presented).

Original languageEnglish
Pages (from-to)8048-8056
Number of pages9
JournalEnvironmental Science and Technology
Volume49
Issue number13
DOIs
Publication statusPublished - 7 Jul 2015
Externally publishedYes

Fingerprint

Pulmonary Surfactants
Chemical stability
Silver
Nanowires
surfactant
microscopy
silver
Microscopic examination
Agglomeration
phospholipid
Linings
Phospholipids
protein
Surface-Active Agents
Fluids
fluid
Proteins
Respiratory system
1,2-Dipalmitoylphosphatidylcholine
Consumer products

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry

Cite this

Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant. / Theodorou, Ioannis G.; Botelho, Danielle; Schwander, Stephan; Zhang, Junfeng; Chung, Kian Fan; Tetley, Teresa D.; Shaffer, Milo S P; Gow, Andrew; Ryan, Mary P.; Porter, Alexandra E.

In: Environmental Science and Technology, Vol. 49, No. 13, 07.07.2015, p. 8048-8056.

Research output: Contribution to journalArticle

Theodorou, IG, Botelho, D, Schwander, S, Zhang, J, Chung, KF, Tetley, TD, Shaffer, MSP, Gow, A, Ryan, MP & Porter, AE 2015, 'Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant', Environmental Science and Technology, vol. 49, no. 13, pp. 8048-8056. https://doi.org/10.1021/acs.est.5b01214
Theodorou, Ioannis G. ; Botelho, Danielle ; Schwander, Stephan ; Zhang, Junfeng ; Chung, Kian Fan ; Tetley, Teresa D. ; Shaffer, Milo S P ; Gow, Andrew ; Ryan, Mary P. ; Porter, Alexandra E. / Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant. In: Environmental Science and Technology. 2015 ; Vol. 49, No. 13. pp. 8048-8056.
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