Abstract
While bio(organic-inorganic) compatibility and absence of cytotoxicity are crucial to create a successful nanocarrier for applications in biosensing and drug delivery [1], the study of its stability before commercialization is quite important. In the present work, the stability of gold nanoparticles (AuNPs) functionalized with L-Cysteine (Cys) and Cysteine-Glycine (Cys-Gly) was studied. The AuNPs surface modification with Cys and CysGly was performed to improve their biocompatibility [2] and, after that, the stability of capped AuNPs was investigated. The synthetized AuNPs using 10 μM of cysteine and 20 μM of Cys demonstrated stability after 1 month of storage, while all other concentration ratios resulted in the formation of chain-like conglomerates. For AuNP capped with CysGly all modifier concentrations led to stable samples within 1 month of storage.
| Original language | English |
|---|---|
| Title of host publication | Advanced Materials Research |
| Pages | 253-258 |
| Number of pages | 6 |
| Volume | 880 |
| DOIs | |
| Publication status | Published - 2014 |
| Event | 10th International Conference on Prospects of Fundamental Sciences Development, PFSD-2013 - Tomsk, Russian Federation Duration: 23 Apr 2013 → 26 Apr 2013 |
Publication series
| Name | Advanced Materials Research |
|---|---|
| Volume | 880 |
| ISSN (Print) | 10226680 |
Other
| Other | 10th International Conference on Prospects of Fundamental Sciences Development, PFSD-2013 |
|---|---|
| Country | Russian Federation |
| City | Tomsk |
| Period | 23.4.13 → 26.4.13 |
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Keywords
- Cysteine
- Functionalization
- Glycine
- Gold
- Gold nanoparticles stabilization
- Nanoparticles
- Sodium citrate
ASJC Scopus subject areas
- Engineering(all)
Cite this
Stability of gold nanoparticles functionalized with aminoacids. / Ramirez-Camacho, M. C.; Tusovskaya, I.; Susarrey-Arce, A.; Pestryakov, A. N.; Bogdanchikova, N.
Advanced Materials Research. Vol. 880 2014. p. 253-258 (Advanced Materials Research; Vol. 880).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Stability of gold nanoparticles functionalized with aminoacids
AU - Ramirez-Camacho, M. C.
AU - Tusovskaya, I.
AU - Susarrey-Arce, A.
AU - Pestryakov, A. N.
AU - Bogdanchikova, N.
PY - 2014
Y1 - 2014
N2 - While bio(organic-inorganic) compatibility and absence of cytotoxicity are crucial to create a successful nanocarrier for applications in biosensing and drug delivery [1], the study of its stability before commercialization is quite important. In the present work, the stability of gold nanoparticles (AuNPs) functionalized with L-Cysteine (Cys) and Cysteine-Glycine (Cys-Gly) was studied. The AuNPs surface modification with Cys and CysGly was performed to improve their biocompatibility [2] and, after that, the stability of capped AuNPs was investigated. The synthetized AuNPs using 10 μM of cysteine and 20 μM of Cys demonstrated stability after 1 month of storage, while all other concentration ratios resulted in the formation of chain-like conglomerates. For AuNP capped with CysGly all modifier concentrations led to stable samples within 1 month of storage.
AB - While bio(organic-inorganic) compatibility and absence of cytotoxicity are crucial to create a successful nanocarrier for applications in biosensing and drug delivery [1], the study of its stability before commercialization is quite important. In the present work, the stability of gold nanoparticles (AuNPs) functionalized with L-Cysteine (Cys) and Cysteine-Glycine (Cys-Gly) was studied. The AuNPs surface modification with Cys and CysGly was performed to improve their biocompatibility [2] and, after that, the stability of capped AuNPs was investigated. The synthetized AuNPs using 10 μM of cysteine and 20 μM of Cys demonstrated stability after 1 month of storage, while all other concentration ratios resulted in the formation of chain-like conglomerates. For AuNP capped with CysGly all modifier concentrations led to stable samples within 1 month of storage.
KW - Cysteine
KW - Functionalization
KW - Glycine
KW - Gold
KW - Gold nanoparticles stabilization
KW - Nanoparticles
KW - Sodium citrate
UR - http://www.scopus.com/inward/record.url?scp=84893906642&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893906642&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/AMR.880.253
DO - 10.4028/www.scientific.net/AMR.880.253
M3 - Conference contribution
AN - SCOPUS:84893906642
SN - 9783038350040
VL - 880
T3 - Advanced Materials Research
SP - 253
EP - 258
BT - Advanced Materials Research
ER -