Spectrophotometric, differential pulse polarographic and differential pulse voltammetric monitoring of the chemical destruction of the anti-tumour pharmaceuticals 6-mercaptopurine, 6-thioguanine and melphalane

Jiří Barek, Antonín Berka, Jiří Zima

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A new method has been developed for the destruction of 6-mercaptopurine, 6-thioguanine and melphalane in laboratory waste, based on oxidation of these substances by potassium permanganate in sulphuric acid medium. To study the effectiveness of the decontamination, spectrophotometric and differential-pulse polarographic methods have been developed for the determination of 6-mercaptopurine and 6-thioguanine and spectrophotometric and differential-pulse voltammetric methods for melphalane. These techniques have been employed to demonstrate that the effectiveness of the proposed method is around 99.8%. Its usefulness for the destruction of various types of expired pharmaceuticals has been demonstrated.

Original languageEnglish
Pages (from-to)987-991
Number of pages5
JournalTalanta
Volume32
Issue number10
DOIs
Publication statusPublished - 1 Jan 1985
Externally publishedYes

Fingerprint

Thioguanine
6-Mercaptopurine
Tumors
Potassium Permanganate
Decontamination
Monitoring
Pharmaceutical Preparations
Oxidation
Acids

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

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abstract = "A new method has been developed for the destruction of 6-mercaptopurine, 6-thioguanine and melphalane in laboratory waste, based on oxidation of these substances by potassium permanganate in sulphuric acid medium. To study the effectiveness of the decontamination, spectrophotometric and differential-pulse polarographic methods have been developed for the determination of 6-mercaptopurine and 6-thioguanine and spectrophotometric and differential-pulse voltammetric methods for melphalane. These techniques have been employed to demonstrate that the effectiveness of the proposed method is around 99.8{\%}. Its usefulness for the destruction of various types of expired pharmaceuticals has been demonstrated.",
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T1 - Spectrophotometric, differential pulse polarographic and differential pulse voltammetric monitoring of the chemical destruction of the anti-tumour pharmaceuticals 6-mercaptopurine, 6-thioguanine and melphalane

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AU - Berka, Antonín

AU - Zima, Jiří

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AB - A new method has been developed for the destruction of 6-mercaptopurine, 6-thioguanine and melphalane in laboratory waste, based on oxidation of these substances by potassium permanganate in sulphuric acid medium. To study the effectiveness of the decontamination, spectrophotometric and differential-pulse polarographic methods have been developed for the determination of 6-mercaptopurine and 6-thioguanine and spectrophotometric and differential-pulse voltammetric methods for melphalane. These techniques have been employed to demonstrate that the effectiveness of the proposed method is around 99.8%. Its usefulness for the destruction of various types of expired pharmaceuticals has been demonstrated.

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