Spectral characteristics and antioxidant properties of tannic acid immobilized on collagen drug-delivery systems

Madalina Georgiana Albu, Mihaela Violeta Ghica, Maria Giurginca, Viorica Trandafir, Lacramioara Popa, Cosmin Cotrut

Research output: Contribution to journalArticle

48 Citations (Scopus)


Tannic acid, a biologic active polyphenol, performs antiviral, antibacterial and antioxidant activity. At the same time, collagen as a natural polymer is widely used in medicine as biomaterial scaffold for tissue regeneration of different types of connective tissue. The aim of this study is to obtain some composite biomaterials with antioxidant activity based on collagen-tannic acid which can be used both as topical formulations and as bioactive dressing for skin wounds. Biomaterials like hydrogels and matrices from collagen gels and tannic acid are obtained by different techniques of conditioning or drying. The antioxidant activity of collagen-tannic acid hydrogels is investigated by chemiluminescence technique (CL) and fluorescence spectroscopy (SF). The chemical-structural characterization of collagen-tannic acid matrices is investigated by UV-VIS-NIR and FT-IR-ATR spectroscopy. The in vitro kinetic release both for collagen hydrogels and matrices proves that these biomaterials can act as bioactive systems for controlled release of tannic acid.

Original languageEnglish
Pages (from-to)666-672
Number of pages7
JournalRevista de Chimie
Issue number7
Publication statusPublished - 1 Jan 2009
Externally publishedYes



  • Antioxidant activity
  • Biomaterials
  • Collagen
  • Kinetic release
  • Tannic acid

ASJC Scopus subject areas

  • Chemistry(all)

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