Abstract
Tannic acid, a biologic active polyphenol, performs antiviral, antibacterial and antioxidant activity. At the same time, collagen as a natural polymer is widely used in medicine as biomaterial scaffold for tissue regeneration of different types of connective tissue. The aim of this study is to obtain some composite biomaterials with antioxidant activity based on collagen-tannic acid which can be used both as topical formulations and as bioactive dressing for skin wounds. Biomaterials like hydrogels and matrices from collagen gels and tannic acid are obtained by different techniques of conditioning or drying. The antioxidant activity of collagen-tannic acid hydrogels is investigated by chemiluminescence technique (CL) and fluorescence spectroscopy (SF). The chemical-structural characterization of collagen-tannic acid matrices is investigated by UV-VIS-NIR and FT-IR-ATR spectroscopy. The in vitro kinetic release both for collagen hydrogels and matrices proves that these biomaterials can act as bioactive systems for controlled release of tannic acid.
| Original language | English |
|---|---|
| Pages (from-to) | 666-672 |
| Number of pages | 7 |
| Journal | Revista de Chimie |
| Volume | 60 |
| Issue number | 7 |
| Publication status | Published - 1 Jan 2009 |
| Externally published | Yes |
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Keywords
- Antioxidant activity
- Biomaterials
- Collagen
- Kinetic release
- Tannic acid
ASJC Scopus subject areas
- Chemistry(all)