Specific features of epithelium-dependent contractile reactions of smooth muscles in various subdivisions of the respiratory tract

L. V. Kapilevich, M. B. Baskakov, Yana Jonovna Anfinogenova, I. V. Kovalyov, M. A. Medvedev

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Characteristic features of the endothelium-dependent smooth muscle contractile reactions to various physiologically active substances modulating adrenergic, cholinergic, and histaminergic regulatory systems are studied in rabbit trachea and in secondary and tertiary bronchi. The mechanical tension of the segments was recorded under quasi-isometric conditions. The epithelium was shown to participate in adrenergic regulation of the smooth muscles of the lower subdivisions of the respiratory tract and in the cholinergic regulation of its upper subdivisions. The histaminergic reactions of the smooth muscles in the airways had large amplitude at all levels, but the relaxing contribution of their epithelium was not detected.

Original languageEnglish
Pages (from-to)1190-1192
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Issue number12
Publication statusPublished - Dec 1998
Externally publishedYes



  • Airways
  • Contractility
  • Epithelium
  • Physiologically active substances
  • Smooth muscles

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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