Specific adrenergic responses of smooth muscles in the vascular wall of guinea pig pulmonary arteries during ovalbumin sensitization

L. V. Kapilevich, A. V. Nosarev, E. Ju Djakova, L. M. Ogorodova, T. N. Zaitseva, K. V. Davletjarova, I. V. Kovalev, M. B. Baskakov, A. E. Sazonov, M. A. Medvedev

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The adrenergic contractile responses of smooth muscles in the vascular wall of guinea pig pulmonary arteries were studied during ovalbumin sensitization. Sensitization was followed by inhibition of contractile responses to an α-adrenoceptor agonist mesatone, prevented endothelium-derived relaxation, and potentiated the contractile response to isoproterenol. Administration of a β-adrenoceptor agonist isoproterenol potentiated the increase in mechanical strain of smooth muscles in the pulmonary artery precontracted with high-potassium Krebs solution. Removal of the endothelium had no effect on the contractile response of smooth muscle segments from the pulmonary artery of intact and sensitized guinea pigs to β-adrenergic influences. The contractile responses of smooth muscles of the pulmonary artery are associated with activity of the cAMP-dependent signal system and play a role in the pathogenesis of ventilation-perfusion disturbances during atopic inflammation.

Original languageEnglish
Pages (from-to)673-675
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume145
Issue number6
DOIs
Publication statusPublished - 2008

Keywords

  • Adrenergic contractile responses
  • Pulmonary arteries
  • Sensitization
  • Smooth muscles

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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