Small cell lung cancer: Constrains and potential of chemoradiotherapy

L. I. Musabaeva, V. A. Lisin, D. Bayrmaa, V. E. Gol'dberg, M. G. Matyash

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Various schemes of applying antitumor drugs and gamma teletherapy among 96 cases of small cell lung cancer (SLC) are analyzed. Consideration is given to the effectiveness of chemoradiotherapy performed in two groups with locally spread SLC (67 patients) and generally spread SLC (29 patients), respectively. A new technique of gamma-neutron therapy of resistant forms of SLC has been developed with the following regimen of neutron therapy. Three fractions were delivered with single focal doses of 2.4 Gy from two opposite fields 10 × 10 cm and of 1.2 By each. An interval of 48-72 h was kept between exposures twice a week. The total focal dose was 7.2 Gy which is isoeffective to 38 Gy. The spatial distribution of dose from fast neutrons evaluated on the basis of a computer program for the dosimetric and radiobiological planning of SLC treatment. Clinical trials applied for 5 patients with follow-up of 4-18 entirely confirmed computed data on maintaining tolerance limits for normal tissues (skin and subcutaneous tissue within the irradiation fields). This limitation constrains the application of neutron therapy with low-energy beams (6.3 mV). An algorithm has been developed for complex chemoradiotherapy of SLC patients to so that the treatment of radiosensitive and radioresistant forms could be differentiated.

    Original languageEnglish
    Pages (from-to)49-57
    Number of pages9
    JournalMeditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
    Volume46
    Issue number2
    Publication statusPublished - 2001

    Keywords

    • Chemoradiotherapy
    • Clinical trials
    • Planning of radiotherapy with fast 6.3 neutrons
    • Small cell lung cancer

    ASJC Scopus subject areas

    • Nuclear Energy and Engineering

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