Single-photon emission computed tomography with 99mtc-1-thio-dglucose for metabolic breast cancer imaging

R. Iu Vernadsky, A. A. Medvedeva, E. Iu Garbukov, I. G. Sinilkin, O. D. Bragina, R. V. Zelchan, E. M. Slonimskaia, V. I. Chernov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Purpose. To evaluate the feasibility of using 99mTc-thio-d-glucose SPECT in the detection of breast cancer. Materials and methods. A prospective study was conducted in 74 patients presenting with palpable masses or abnormal mammography/ultrasound scheduled for biopsy. All patients underwent SPECT with 99mTc-TG. The mean age was 44 years (range 30-79 years) Results. Focal accumulation of radiopharmaceutical in breast were detected in 43 cases. The mean tumor-to-background ratio uptake was 1,87±0,82 and had a weak but significant positive correlation with Ki-67 and a negative correlation with mammography density. The sensitivity for cancer diagnosis was 55.55% and specificity 78.57%. SPECT showed axillary lesions in 6/26 (23%) patients with axillary lymph node metastasis. In the group of postmenopausal women, the sensitivity of the study was 72%, in postmenopausal patients with a tumor size of 2 cm or more, SPECT sensitivity with 99mTc-TG increased to 77%. The low sensitivity in detecting a primary tumor was associated with bilateral diffuse uptake of radiopharmaceutical. Bilateral high-intensity inclusion of the drug was recorded in 27 patients with breast cancer. Bilateral accumulation of the drug is associated with a younger age (p = 0.011), active menstrual status (p = 0.006) and high mammographic density (p = 0.001). Conclusion. 99mTc-TG SPECT can be used as an additional research method to assess the metabolism of lesion in postmenopausal patients with tumor sizes of more than 2 cm. In young premenopausal women with small tumor sizes, the method has low diagnostic efficiency and is not indicated for use.

Original languageEnglish
Pages (from-to)82-96
Number of pages15
JournalRussian Electronic Journal of Radiology
Issue number4
Publication statusPublished - 2019
Externally publishedYes


  • 1-thio-D-glucose
  • Breast cancer
  • Radiopharmaceutical
  • Technetium-99m

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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