Abstract
A procedure is proposed for the determination of succinic acid, riboxin, nicotinamide, and riboflavin by ion-pair HPLC with UV detection. Owing to the addition of an ion-pair modifier to the mobile phase and the selection of gradient elution conditions, the optimal retention and resolution of peaks of the components to be determined are achieved. Specificity, linearity, accuracy, and precision of the developed procedure are proved on an example of the determination of active substances in the Cerebronorm® preparation.
| Original language | English |
|---|---|
| Pages (from-to) | 358-363 |
| Number of pages | 6 |
| Journal | Journal of Analytical Chemistry |
| Volume | 73 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Apr 2018 |
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Keywords
- Cerebronorm®
- gradient elution
- ion-pair HPLC
- succinic acid
- water-soluble vitamins
ASJC Scopus subject areas
- Analytical Chemistry
Cite this
Simultaneous Determination of Succinic Acid and Water-Soluble Vitamins by Ion-Pair High-Performance Liquid Chromatography. / Leonov, K. A.; Pustovoitov, A. V.; Vishenkova, D. A.
In: Journal of Analytical Chemistry, Vol. 73, No. 4, 01.04.2018, p. 358-363.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Simultaneous Determination of Succinic Acid and Water-Soluble Vitamins by Ion-Pair High-Performance Liquid Chromatography
AU - Leonov, K. A.
AU - Pustovoitov, A. V.
AU - Vishenkova, D. A.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - A procedure is proposed for the determination of succinic acid, riboxin, nicotinamide, and riboflavin by ion-pair HPLC with UV detection. Owing to the addition of an ion-pair modifier to the mobile phase and the selection of gradient elution conditions, the optimal retention and resolution of peaks of the components to be determined are achieved. Specificity, linearity, accuracy, and precision of the developed procedure are proved on an example of the determination of active substances in the Cerebronorm® preparation.
AB - A procedure is proposed for the determination of succinic acid, riboxin, nicotinamide, and riboflavin by ion-pair HPLC with UV detection. Owing to the addition of an ion-pair modifier to the mobile phase and the selection of gradient elution conditions, the optimal retention and resolution of peaks of the components to be determined are achieved. Specificity, linearity, accuracy, and precision of the developed procedure are proved on an example of the determination of active substances in the Cerebronorm® preparation.
KW - Cerebronorm®
KW - gradient elution
KW - ion-pair HPLC
KW - succinic acid
KW - water-soluble vitamins
UR - http://www.scopus.com/inward/record.url?scp=85045760061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045760061&partnerID=8YFLogxK
U2 - 10.1134/S1061934818040068
DO - 10.1134/S1061934818040068
M3 - Article
VL - 73
SP - 358
EP - 363
JO - Journal of Analytical Chemistry
JF - Journal of Analytical Chemistry
SN - 1061-9348
IS - 4
ER -