Similar cardiovascular and autonomic responses in trained type 1 diabetes mellitus and healthy participants in response to half marathon

Laurent Mourot, Alessandro Fornasiero, Mark Rakobowchuk, Spyros Skafidas, Alfredo Brighenti, Federico Stella, Andrea Zignoli, Aldo Savoldelli, Barbara Pellegrini, Elisa Danese, Giuseppe Lippi, Cantor Tarperi, Federico Schena

Research output: Contribution to journalArticle

Abstract

Aims: This field experiment examined whether trained people with type 1 diabetes mellitus (T1D) have similar cardiovascular and baroreflex alterations after a 21-km running race when compared to healthy people. Methods: Nine T1D (39.0 ± 11.1 yr; 175.0 ± 10.2 cm; 70.8 ± 8.7 kg) were matched with 9 healthy participants (42.4 ± 5.8 yr; 175.7 ± 6.7 cm; 72.1 ± 8.5 kg) who ran an official half-marathon. Before and 1-hour after the race, cardiovascular variables, sympathetic activity (catecholamines), parasympathetic (heart rate variability analysis) modulation and cardiac baroreflex function (transfer function analysis) were assessed during supine rest and a squat stand test (forced blood pressure change). Results: Performance time and weight loss [104.0 ± 13.2 and 111.0 ± 18.7 min; −2.57 ± 1.05 kg (−1.88 ± 0.88%) and −2.29 ± 1.15 kg (−1.59 ± 0.59%)] for healthy and T1D participants, respectively) were similar. Before running, no significant differences in any cardiovascular or autonomic variables were noted between the groups. After 1 h of recovery, both groups exhibited post-exercise hypotension, accompanied by increased sympathetic activity, decreased parasympathetic modulation, and reduced cardiac baroreflex sensitivity. Conclusions: Our results showed that the pattern of change in cardiovascular and autonomic nervous activity to strenuous exercise are well maintained in T1D participants with a training history of at least 5 years.

Original languageEnglish
Article number107995
JournalDiabetes Research and Clinical Practice
Volume160
DOIs
Publication statusPublished - Feb 2020

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Keywords

  • Baroreflex
  • Half-marathon
  • Parasympathetic
  • Squat stand test
  • Sympathetic

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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