Silica microcarriers produced from a microfluidics-generated emulsion

Abstract

Fabrication of micrometric and submicrometric capsules capable of carrying bioactive substances is important for many biological applications. Here we show the results of our work on creating water-in-oil emulsion and encasing the water droplets in silica shell with microfluidic techniques. The emulsion was generated in a polydimethylsiloxane (PDMS) flowfocusing microfluidic chip. TWEEN 80 and lecithin were used as surfactants to stabilize the emulsion. Tetraethylorthosilicate (TEOS) and 3-aminopropyl trimethoxysilane (APTMOS) were then added to the emulsion to form silica shell around water droplets via hydrolysis. We obtained silica microcapsules of about 2 μm in diameter and studied them using confocal fluorescent microscopy. This method allows encapsulating a wide range of sensitive substances including genetic material, enzymes, proteins for intracellular delivery and other biomedical applications.

Original language	English
Article number	012155
Journal	Journal of Physics: Conference Series
Volume	1092
DOIs	https://doi.org/10.1088/1742-6596/1092/1/012155
Publication status	Published - 2018
Externally published	Yes
Event	3rd International Conference on Metamaterials and Nanophotonics, METANANO 2018 - Sochi, Russian Federation Duration: 17 Sep 2018 → 21 Sep 2018

ASJC Scopus subject areas

Physics and Astronomy(all)

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10.1088/1742-6596/1092/1/012155

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@article{76ad1543c618414fb58d136082985ba6,

title = "Silica microcarriers produced from a microfluidics-generated emulsion",

abstract = "Fabrication of micrometric and submicrometric capsules capable of carrying bioactive substances is important for many biological applications. Here we show the results of our work on creating water-in-oil emulsion and encasing the water droplets in silica shell with microfluidic techniques. The emulsion was generated in a polydimethylsiloxane (PDMS) flowfocusing microfluidic chip. TWEEN 80 and lecithin were used as surfactants to stabilize the emulsion. Tetraethylorthosilicate (TEOS) and 3-aminopropyl trimethoxysilane (APTMOS) were then added to the emulsion to form silica shell around water droplets via hydrolysis. We obtained silica microcapsules of about 2 μm in diameter and studied them using confocal fluorescent microscopy. This method allows encapsulating a wide range of sensitive substances including genetic material, enzymes, proteins for intracellular delivery and other biomedical applications.",

author = "Trofimov, {A. D.} and Goncharenko, {A. A.} and Muslimov, {A. R.} and Timin, {A. S.} and Zyuzin, {M. V.} and Evstrapov, {A. A.}",

note = "Funding Information: MVZ thanks the Russian Science Foundation (grant No 17-19-01637). Publisher Copyright: {\textcopyright} 2018 Institute of Physics Publishing.All Rights Reserved. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.; 3rd International Conference on Metamaterials and Nanophotonics, METANANO 2018 ; Conference date: 17-09-2018 Through 21-09-2018",

year = "2018",

doi = "10.1088/1742-6596/1092/1/012155",

language = "English",

volume = "1092",

journal = "Journal of Physics: Conference Series",

issn = "1742-6588",

publisher = "IOP Publishing Ltd.",

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TY - JOUR

T1 - Silica microcarriers produced from a microfluidics-generated emulsion

AU - Trofimov, A. D.

AU - Goncharenko, A. A.

AU - Muslimov, A. R.

AU - Timin, A. S.

AU - Zyuzin, M. V.

AU - Evstrapov, A. A.

N1 - Funding Information: MVZ thanks the Russian Science Foundation (grant No 17-19-01637). Publisher Copyright: © 2018 Institute of Physics Publishing.All Rights Reserved. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2018

Y1 - 2018

N2 - Fabrication of micrometric and submicrometric capsules capable of carrying bioactive substances is important for many biological applications. Here we show the results of our work on creating water-in-oil emulsion and encasing the water droplets in silica shell with microfluidic techniques. The emulsion was generated in a polydimethylsiloxane (PDMS) flowfocusing microfluidic chip. TWEEN 80 and lecithin were used as surfactants to stabilize the emulsion. Tetraethylorthosilicate (TEOS) and 3-aminopropyl trimethoxysilane (APTMOS) were then added to the emulsion to form silica shell around water droplets via hydrolysis. We obtained silica microcapsules of about 2 μm in diameter and studied them using confocal fluorescent microscopy. This method allows encapsulating a wide range of sensitive substances including genetic material, enzymes, proteins for intracellular delivery and other biomedical applications.

AB - Fabrication of micrometric and submicrometric capsules capable of carrying bioactive substances is important for many biological applications. Here we show the results of our work on creating water-in-oil emulsion and encasing the water droplets in silica shell with microfluidic techniques. The emulsion was generated in a polydimethylsiloxane (PDMS) flowfocusing microfluidic chip. TWEEN 80 and lecithin were used as surfactants to stabilize the emulsion. Tetraethylorthosilicate (TEOS) and 3-aminopropyl trimethoxysilane (APTMOS) were then added to the emulsion to form silica shell around water droplets via hydrolysis. We obtained silica microcapsules of about 2 μm in diameter and studied them using confocal fluorescent microscopy. This method allows encapsulating a wide range of sensitive substances including genetic material, enzymes, proteins for intracellular delivery and other biomedical applications.

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DO - 10.1088/1742-6596/1092/1/012155

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VL - 1092

JO - Journal of Physics: Conference Series

JF - Journal of Physics: Conference Series

SN - 1742-6588

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T2 - 3rd International Conference on Metamaterials and Nanophotonics, METANANO 2018

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