Silica microcarriers produced from a microfluidics-generated emulsion

A. D. Trofimov, A. A. Goncharenko, A. R. Muslimov, A. S. Timin, M. V. Zyuzin, A. A. Evstrapov

Research output: Contribution to journalConference articlepeer-review

Abstract

Fabrication of micrometric and submicrometric capsules capable of carrying bioactive substances is important for many biological applications. Here we show the results of our work on creating water-in-oil emulsion and encasing the water droplets in silica shell with microfluidic techniques. The emulsion was generated in a polydimethylsiloxane (PDMS) flowfocusing microfluidic chip. TWEEN 80 and lecithin were used as surfactants to stabilize the emulsion. Tetraethylorthosilicate (TEOS) and 3-aminopropyl trimethoxysilane (APTMOS) were then added to the emulsion to form silica shell around water droplets via hydrolysis. We obtained silica microcapsules of about 2 μm in diameter and studied them using confocal fluorescent microscopy. This method allows encapsulating a wide range of sensitive substances including genetic material, enzymes, proteins for intracellular delivery and other biomedical applications.

Original languageEnglish
Article number012155
JournalJournal of Physics: Conference Series
Volume1092
DOIs
Publication statusPublished - 2018
Externally publishedYes
Event3rd International Conference on Metamaterials and Nanophotonics, METANANO 2018 - Sochi, Russian Federation
Duration: 17 Sep 201821 Sep 2018

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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