Abstract
Fabrication of micrometric and submicrometric capsules capable of carrying bioactive substances is important for many biological applications. Here we show the results of our work on creating water-in-oil emulsion and encasing the water droplets in silica shell with microfluidic techniques. The emulsion was generated in a polydimethylsiloxane (PDMS) flowfocusing microfluidic chip. TWEEN 80 and lecithin were used as surfactants to stabilize the emulsion. Tetraethylorthosilicate (TEOS) and 3-aminopropyl trimethoxysilane (APTMOS) were then added to the emulsion to form silica shell around water droplets via hydrolysis. We obtained silica microcapsules of about 2 μm in diameter and studied them using confocal fluorescent microscopy. This method allows encapsulating a wide range of sensitive substances including genetic material, enzymes, proteins for intracellular delivery and other biomedical applications.
Original language | English |
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Article number | 012155 |
Journal | Journal of Physics: Conference Series |
Volume | 1092 |
DOIs | |
Publication status | Published - 2018 |
Externally published | Yes |
Event | 3rd International Conference on Metamaterials and Nanophotonics, METANANO 2018 - Sochi, Russian Federation Duration: 17 Sep 2018 → 21 Sep 2018 |
ASJC Scopus subject areas
- Physics and Astronomy(all)