TY - JOUR
T1 - Serum bdnf’s role as a biomarker for motor training in the context of ar-based rehabilitation after ischemic stroke
AU - Koroleva, Ekaterina S.
AU - Tolmachev, Ivan V.
AU - Alifirova, Valentina M.
AU - Boiko, Anastasiia S.
AU - Levchuk, Lyudmila A.
AU - Loonen, Anton J.M.
AU - Ivanova, Svetlana A.
N1 - Funding Information:
Funding: This research (including the development of the NeuroRAR program) was funded by the Russian Science Foundation (RSF), grant no. 18-15-00082 “Laboratory for robotic rehabilitation”. Science Foundation (RSF), grant no. 18-15-00082 “Laboratory for robotic rehabilitation”. Conflicts of Interest: The authors declare no conflict of interest. Conflicts of Interest: The authors declare no conflict of interest.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9
Y1 - 2020/9
N2 - Background: brain-derived neurotrophic factor (BDNF) may play a role during neurorehabilitation following ischemic stroke. This study aimed to elucidate the possible role of BDNF during early recovery from ischemic stroke assisted by motor training. Methods: fifty patients were included after acute recovery from ischemic stroke: 21 first received classical rehabilitation followed by ‘motor rehabilitation using motion sensors and augmented reality’ (AR-rehabilitation), 14 only received AR-rehabilitation, and 15 were only observed. Serum BDNF levels were measured on the first day of stroke, on the 14th day, before AR-based rehabilitation (median, 45th day), and after the AR-based rehabilitation (median, 82nd day). Motor impairment was quantified clinically using the Fugl–Meyer scale (FMA); functional disability and activities of daily living (ADL) were measured using the Modified Rankin Scale (mRS). For comparison, serum BDNF was measured in 50 healthy individuals. Results: BDNF levels were found to significantly increase during the phase with AR-based rehabilitation. The pattern of the sequentially measured BDNF levels was similar in the treated patients. Untreated patients had significantly lower BDNF levels at the endpoint. Conclusions: the fluctuations of BDNF levels are not consistently related to motor improvement but seem to react to active treatment. Without active rehabilitation treatment, BDNF tends to decrease.
AB - Background: brain-derived neurotrophic factor (BDNF) may play a role during neurorehabilitation following ischemic stroke. This study aimed to elucidate the possible role of BDNF during early recovery from ischemic stroke assisted by motor training. Methods: fifty patients were included after acute recovery from ischemic stroke: 21 first received classical rehabilitation followed by ‘motor rehabilitation using motion sensors and augmented reality’ (AR-rehabilitation), 14 only received AR-rehabilitation, and 15 were only observed. Serum BDNF levels were measured on the first day of stroke, on the 14th day, before AR-based rehabilitation (median, 45th day), and after the AR-based rehabilitation (median, 82nd day). Motor impairment was quantified clinically using the Fugl–Meyer scale (FMA); functional disability and activities of daily living (ADL) were measured using the Modified Rankin Scale (mRS). For comparison, serum BDNF was measured in 50 healthy individuals. Results: BDNF levels were found to significantly increase during the phase with AR-based rehabilitation. The pattern of the sequentially measured BDNF levels was similar in the treated patients. Untreated patients had significantly lower BDNF levels at the endpoint. Conclusions: the fluctuations of BDNF levels are not consistently related to motor improvement but seem to react to active treatment. Without active rehabilitation treatment, BDNF tends to decrease.
KW - Augmented reality (AR)-biofeedback motion training
KW - BDNF
KW - Functional rewiring
KW - Ischemic stroke
KW - Long-term potentiation
KW - Rehabilitation
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U2 - 10.3390/brainsci10090623
DO - 10.3390/brainsci10090623
M3 - Article
AN - SCOPUS:85090670477
VL - 10
SP - 1
EP - 19
JO - Brain Sciences
JF - Brain Sciences
SN - 2076-3425
IS - 9
M1 - 623
ER -