SERS platform for detection of lipids and disease markers prepared using modification of plasmonic-active gold gratings by lipophilic moieties

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Abstract

New functional SERS platform for effective detection of lipophilic disease markers was proposed and realized. The work was aimed at the achievement of highly-reproducible SERS results obtained in shorter measuring times. The homogeneous plasmon distribution was achieved through the introduction of large area surface plasmon-polariton supported substrate with a good smearing of plasmon intensity along the working substrate area. Homogeneous distribution of targeted lipophilic molecules on the SERS surface was realized through the surface grafting with alkylaryl moieties of various carbon chain lengths via diazonium chemistry. The process of modification was followed and confirmed by XPS and Raman methods. The functionality of created SERS substrates was studied by the contact angle measurement and CVA methods. The possibility of detection of two biomedically significant molecules (squalene and β-sitosterol) was examined. Dependence of the SERS results on the aliphatic chain lengths was tested in the terms of targeted molecules SERS intensity and reproducibility. The prepared SERS substrates were found to be suitable for sensing of squalene and β-sitosterol at the biorelevant μM concentration level.

Original languageEnglish
Pages (from-to)182-192
Number of pages11
JournalSensors and Actuators, B: Chemical
Volume265
DOIs
Publication statusPublished - 15 Jul 2018

Fingerprint

Gold
markers
Lipids
lipids
platforms
gratings
gold
Squalene
Substrates
Chain length
Molecules
molecules
Angle measurement
polaritons
Contact angle
Carbon
X ray photoelectron spectroscopy
chemistry
carbon
gamma-sitosterol

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

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title = "SERS platform for detection of lipids and disease markers prepared using modification of plasmonic-active gold gratings by lipophilic moieties",
abstract = "New functional SERS platform for effective detection of lipophilic disease markers was proposed and realized. The work was aimed at the achievement of highly-reproducible SERS results obtained in shorter measuring times. The homogeneous plasmon distribution was achieved through the introduction of large area surface plasmon-polariton supported substrate with a good smearing of plasmon intensity along the working substrate area. Homogeneous distribution of targeted lipophilic molecules on the SERS surface was realized through the surface grafting with alkylaryl moieties of various carbon chain lengths via diazonium chemistry. The process of modification was followed and confirmed by XPS and Raman methods. The functionality of created SERS substrates was studied by the contact angle measurement and CVA methods. The possibility of detection of two biomedically significant molecules (squalene and β-sitosterol) was examined. Dependence of the SERS results on the aliphatic chain lengths was tested in the terms of targeted molecules SERS intensity and reproducibility. The prepared SERS substrates were found to be suitable for sensing of squalene and β-sitosterol at the biorelevant μM concentration level.",
author = "Olga Guselnikova and Yevgeniya Kalachyova and Karolina Hrobonova and Marina Trusova and Jiri Barek and Pavel Postnikov and Vaclav Svorcik and Oleksiy Lyutakov",
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T1 - SERS platform for detection of lipids and disease markers prepared using modification of plasmonic-active gold gratings by lipophilic moieties

AU - Guselnikova, Olga

AU - Kalachyova, Yevgeniya

AU - Hrobonova, Karolina

AU - Trusova, Marina

AU - Barek, Jiri

AU - Postnikov, Pavel

AU - Svorcik, Vaclav

AU - Lyutakov, Oleksiy

PY - 2018/7/15

Y1 - 2018/7/15

N2 - New functional SERS platform for effective detection of lipophilic disease markers was proposed and realized. The work was aimed at the achievement of highly-reproducible SERS results obtained in shorter measuring times. The homogeneous plasmon distribution was achieved through the introduction of large area surface plasmon-polariton supported substrate with a good smearing of plasmon intensity along the working substrate area. Homogeneous distribution of targeted lipophilic molecules on the SERS surface was realized through the surface grafting with alkylaryl moieties of various carbon chain lengths via diazonium chemistry. The process of modification was followed and confirmed by XPS and Raman methods. The functionality of created SERS substrates was studied by the contact angle measurement and CVA methods. The possibility of detection of two biomedically significant molecules (squalene and β-sitosterol) was examined. Dependence of the SERS results on the aliphatic chain lengths was tested in the terms of targeted molecules SERS intensity and reproducibility. The prepared SERS substrates were found to be suitable for sensing of squalene and β-sitosterol at the biorelevant μM concentration level.

AB - New functional SERS platform for effective detection of lipophilic disease markers was proposed and realized. The work was aimed at the achievement of highly-reproducible SERS results obtained in shorter measuring times. The homogeneous plasmon distribution was achieved through the introduction of large area surface plasmon-polariton supported substrate with a good smearing of plasmon intensity along the working substrate area. Homogeneous distribution of targeted lipophilic molecules on the SERS surface was realized through the surface grafting with alkylaryl moieties of various carbon chain lengths via diazonium chemistry. The process of modification was followed and confirmed by XPS and Raman methods. The functionality of created SERS substrates was studied by the contact angle measurement and CVA methods. The possibility of detection of two biomedically significant molecules (squalene and β-sitosterol) was examined. Dependence of the SERS results on the aliphatic chain lengths was tested in the terms of targeted molecules SERS intensity and reproducibility. The prepared SERS substrates were found to be suitable for sensing of squalene and β-sitosterol at the biorelevant μM concentration level.

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