Separation of two labeled components of [<sup>111</sup>In]-OctreoScan by HPLC

Abstract

[¹¹¹In]-DTPA-D-Phe¹-octreotide (OctreoScan®, Mallinkrodt) is widely used for detection of neuroendocrine tumors and has lately been proposed for radionuclide therapy. We found, using HPLC and a GF-250 column (Zorbax®, Hewlett Packard), that OctreoScan® can be separated in two radiolabeled components of about equal amount. The analytical conditions for a quantitative isolation indicate that the two-peptide components of OctreoScan® have different lipophilicity. The isolated components are stable and do not transform into each other at room temperature during 6 hours (shelf-life of OctreoScan®).

Original language	English
Pages (from-to)	95-99
Number of pages	5
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	247
Issue number	1
DOIs	https://doi.org/10.1023/A:1006715114925
Publication status	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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title = "Separation of two labeled components of [111In]-OctreoScan by HPLC",

abstract = "[111In]-DTPA-D-Phe1-octreotide (OctreoScan{\textregistered}, Mallinkrodt) is widely used for detection of neuroendocrine tumors and has lately been proposed for radionuclide therapy. We found, using HPLC and a GF-250 column (Zorbax{\textregistered}, Hewlett Packard), that OctreoScan{\textregistered} can be separated in two radiolabeled components of about equal amount. The analytical conditions for a quantitative isolation indicate that the two-peptide components of OctreoScan{\textregistered} have different lipophilicity. The isolated components are stable and do not transform into each other at room temperature during 6 hours (shelf-life of OctreoScan{\textregistered}).",

author = "A. Bruskin and V. Tolmachev and Westlin, {J. E.} and H. Lundqvist",

note = "Funding Information: The authors would like to thank The Svedberg Laboratory for technical help and the Swedish Cancer Foundation and the Swedish Royal Academy of Sciences for financial support. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

year = "2001",

doi = "10.1023/A:1006715114925",

language = "English",

volume = "247",

pages = "95--99",

journal = "Journal of Radioanalytical and Nuclear Chemistry",

issn = "0236-5731",

publisher = "Elsevier BV",

number = "1",

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TY - JOUR

T1 - Separation of two labeled components of [111In]-OctreoScan by HPLC

AU - Bruskin, A.

AU - Tolmachev, V.

AU - Westlin, J. E.

AU - Lundqvist, H.

N1 - Funding Information: The authors would like to thank The Svedberg Laboratory for technical help and the Swedish Cancer Foundation and the Swedish Royal Academy of Sciences for financial support. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 2001

Y1 - 2001

N2 - [111In]-DTPA-D-Phe1-octreotide (OctreoScan®, Mallinkrodt) is widely used for detection of neuroendocrine tumors and has lately been proposed for radionuclide therapy. We found, using HPLC and a GF-250 column (Zorbax®, Hewlett Packard), that OctreoScan® can be separated in two radiolabeled components of about equal amount. The analytical conditions for a quantitative isolation indicate that the two-peptide components of OctreoScan® have different lipophilicity. The isolated components are stable and do not transform into each other at room temperature during 6 hours (shelf-life of OctreoScan®).

AB - [111In]-DTPA-D-Phe1-octreotide (OctreoScan®, Mallinkrodt) is widely used for detection of neuroendocrine tumors and has lately been proposed for radionuclide therapy. We found, using HPLC and a GF-250 column (Zorbax®, Hewlett Packard), that OctreoScan® can be separated in two radiolabeled components of about equal amount. The analytical conditions for a quantitative isolation indicate that the two-peptide components of OctreoScan® have different lipophilicity. The isolated components are stable and do not transform into each other at room temperature during 6 hours (shelf-life of OctreoScan®).

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JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

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Separation of two labeled components of [¹¹¹In]-OctreoScan by HPLC

Abstract

ASJC Scopus subject areas

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