Secretory Function of Skeletal Muscles: Producing Mechanisms and Myokines Physiological Effects

L. V. Kapilevich, A. V. Kabachkova, A. N. Zakharova, G. S. Lalaeva, T. A. Kironenko, E. Yu Dyakova, S. N. Orlov

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Skeletal muscle cells secrete a variety of hormones and cytokines, which are referred to as myokines. Different modes of exercise are the main factor of myokines producing. The myokines expression level is increased in an exponential fashon proportional to the length of exercise and the amount of muscle mass engaged in the exercise. These myokines are described to communicate with cells in an autocrine/ paracrine manner. Thus it ensures the maintenance of homeostasis and adaptarion to physical stress. This myokines role is provided by a vriety of effects. It is assumed that exercise increases myokines transcription via signaling systems that are activated in response to a decrease in the partial pressure of oxygen, increasing the concentration of [Ca²⁺] i and AMP. Significant prospects have the myokines investigation of the role in the different disorders correction. So now accumulated enough data for myokines consideration as a single functional system, which plays an important role in the adaptation mechanisms to the habitual exrcise.

Original languageEnglish
Pages (from-to)7-26
Number of pages20
JournalUspekhi Fiziologicheskikh Nauk
Issue number2
Publication statusPublished - 1 Apr 2016

ASJC Scopus subject areas

  • Physiology

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