Searching for new synthetic diuretics

I. V. Smirnov, T. O. Murashko, A. A. Ivanov, A. O. Nemtsev, A. A. Bondarev, V. V. Udut

Shared Knowledge Center "Physical and Chemical Analysis Methods"

Research output: Contribution to journal › Article

Abstract

This study was aimed at estimation of the diuretic and saluretic activity of 4-nitrophenyl-O-β-D-glucopyranoside and its aglicon 4-nitrophenol in rats. Test animals daily received 4-nitrophenyl-O-β-D-glucopyranoside (group 1) and 4-nitrophenol (group 2) intragastrically in 2 mL of distilled water in a dose of 18 μ mol/kg from 1st to 7th day and 54 |jmol/kg from 8th to 14th days. During the experiment, the most pronounced diuretic activity was observed for 4-nitrophe-nyl-O-β-D-glucopyranoside in a dose of 54 μmol/kg, which increased the diuresis in rats 2.5 times as compared to the control value.

Original language	English
Pages (from-to)	3-5
Number of pages	3
Journal	Eksperimental'naya i Klinicheskaya Farmakologiya
Volume	78
Issue number	12
Publication status	Published - 1 Jan 2015

Fingerprint

Diuretics

Rats

Diuresis

Animals

Water

Experiments

4-nitrophenol

4-nitrophenyl

Keywords

Diuretics
Preclinical investigation

ASJC Scopus subject areas

Toxicology
Pharmacology

Cite this

Smirnov, I. V., Murashko, T. O., Ivanov, A. A., Nemtsev, A. O., Bondarev, A. A., & Udut, V. V. (2015). Searching for new synthetic diuretics. Eksperimental'naya i Klinicheskaya Farmakologiya, 78(12), 3-5.

Searching for new synthetic diuretics. / Smirnov, I. V.; Murashko, T. O.; Ivanov, A. A.; Nemtsev, A. O.; Bondarev, A. A.; Udut, V. V.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 78, No. 12, 01.01.2015, p. 3-5.

Research output: Contribution to journal › Article

Smirnov, IV, Murashko, TO, Ivanov, AA, Nemtsev, AO, Bondarev, AA & Udut, VV 2015, 'Searching for new synthetic diuretics', Eksperimental'naya i Klinicheskaya Farmakologiya, vol. 78, no. 12, pp. 3-5.

Smirnov IV, Murashko TO, Ivanov AA, Nemtsev AO, Bondarev AA, Udut VV. Searching for new synthetic diuretics. Eksperimental'naya i Klinicheskaya Farmakologiya. 2015 Jan 1;78(12):3-5.

Smirnov, I. V. ; Murashko, T. O. ; Ivanov, A. A. ; Nemtsev, A. O. ; Bondarev, A. A. ; Udut, V. V. / Searching for new synthetic diuretics. In: Eksperimental'naya i Klinicheskaya Farmakologiya. 2015 ; Vol. 78, No. 12. pp. 3-5.

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