Searching for new synthetic diuretics

I. V. Smirnov, T. O. Murashko, A. A. Ivanov, A. O. Nemtsev, A. A. Bondarev, V. V. Udut

Research output: Contribution to journalArticle

Abstract

This study was aimed at estimation of the diuretic and saluretic activity of 4-nitrophenyl-O-β-D-glucopyranoside and its aglicon 4-nitrophenol in rats. Test animals daily received 4-nitrophenyl-O-β-D-glucopyranoside (group 1) and 4-nitrophenol (group 2) intragastrically in 2 mL of distilled water in a dose of 18 μ mol/kg from 1st to 7th day and 54 |jmol/kg from 8th to 14th days. During the experiment, the most pronounced diuretic activity was observed for 4-nitrophe-nyl-O-β-D-glucopyranoside in a dose of 54 μmol/kg, which increased the diuresis in rats 2.5 times as compared to the control value.

Original languageEnglish
Pages (from-to)3-5
Number of pages3
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume78
Issue number12
Publication statusPublished - 1 Jan 2015

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Keywords

  • Diuretics
  • Preclinical investigation

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Smirnov, I. V., Murashko, T. O., Ivanov, A. A., Nemtsev, A. O., Bondarev, A. A., & Udut, V. V. (2015). Searching for new synthetic diuretics. Eksperimental'naya i Klinicheskaya Farmakologiya, 78(12), 3-5.