Searching for new synthetic diuretics

I. V. Smirnov, T. O. Murashko, A. A. Ivanov, A. O. Nemtsev, A. A. Bondarev, V. V. Udut

Research output: Contribution to journal › Article

Abstract

This study was aimed at estimation of the diuretic and saluretic activity of 4-nitrophenyl-O-β-D-glucopyranoside and its aglicon 4-nitrophenol in rats. Test animals daily received 4-nitrophenyl-O-β-D-glucopyranoside (group 1) and 4-nitrophenol (group 2) intragastrically in 2 mL of distilled water in a dose of 18 μ mol/kg from 1st to 7th day and 54 |jmol/kg from 8th to 14th days. During the experiment, the most pronounced diuretic activity was observed for 4-nitrophe-nyl-O-β-D-glucopyranoside in a dose of 54 μmol/kg, which increased the diuresis in rats 2.5 times as compared to the control value.

Original languageEnglish
Pages (from-to)3-5
Number of pages3
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume78
Issue number12
Publication statusPublished - 1 Jan 2015

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Diuretics
Rats
Diuresis
Animals
Water
Experiments
4-nitrophenol
4-nitrophenyl

Keywords

  • Diuretics
  • Preclinical investigation

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Smirnov, I. V., Murashko, T. O., Ivanov, A. A., Nemtsev, A. O., Bondarev, A. A., & Udut, V. V. (2015). Searching for new synthetic diuretics. Eksperimental'naya i Klinicheskaya Farmakologiya, 78(12), 3-5.

Searching for new synthetic diuretics. / Smirnov, I. V.; Murashko, T. O.; Ivanov, A. A.; Nemtsev, A. O.; Bondarev, A. A.; Udut, V. V.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 78, No. 12, 01.01.2015, p. 3-5.

Research output: Contribution to journal › Article

Smirnov, IV, Murashko, TO, Ivanov, AA, Nemtsev, AO, Bondarev, AA & Udut, VV 2015, 'Searching for new synthetic diuretics', Eksperimental'naya i Klinicheskaya Farmakologiya, vol. 78, no. 12, pp. 3-5.
Smirnov IV, Murashko TO, Ivanov AA, Nemtsev AO, Bondarev AA, Udut VV. Searching for new synthetic diuretics. Eksperimental'naya i Klinicheskaya Farmakologiya. 2015 Jan 1;78(12):3-5.
Smirnov, I. V. ; Murashko, T. O. ; Ivanov, A. A. ; Nemtsev, A. O. ; Bondarev, A. A. ; Udut, V. V. / Searching for new synthetic diuretics. In: Eksperimental'naya i Klinicheskaya Farmakologiya. 2015 ; Vol. 78, No. 12. pp. 3-5.
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