Searching for new synthetic diuretics

I. V. Smirnov, T. O. Murashko, A. A. Ivanov, A. O. Nemtsev, A. A. Bondarev, V. V. Udut

Shared Knowledge Center "Physical and Chemical Analysis Methods"

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Abstract

This study was aimed at estimation of the diuretic and saluretic activity of 4-nitrophenyl-O-β-D-glucopyranoside and its aglicon 4-nitrophenol in rats. Test animals daily received 4-nitrophenyl-O-β-D-glucopyranoside (group 1) and 4-nitrophenol (group 2) intragastrically in 2 mL of distilled water in a dose of 18 μ mol/kg from 1st to 7th day and 54 |jmol/kg from 8th to 14th days. During the experiment, the most pronounced diuretic activity was observed for 4-nitrophe-nyl-O-β-D-glucopyranoside in a dose of 54 μmol/kg, which increased the diuresis in rats 2.5 times as compared to the control value.

Original language	English
Pages (from-to)	3-5
Number of pages	3
Journal	Eksperimental'naya i Klinicheskaya Farmakologiya
Volume	78
Issue number	12
Publication status	Published - 1 Jan 2015

Keywords

Diuretics
Preclinical investigation

ASJC Scopus subject areas

Toxicology
Pharmacology

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title = "Searching for new synthetic diuretics",

abstract = "This study was aimed at estimation of the diuretic and saluretic activity of 4-nitrophenyl-O-β-D-glucopyranoside and its aglicon 4-nitrophenol in rats. Test animals daily received 4-nitrophenyl-O-β-D-glucopyranoside (group 1) and 4-nitrophenol (group 2) intragastrically in 2 mL of distilled water in a dose of 18 μ mol/kg from 1st to 7th day and 54 |jmol/kg from 8th to 14th days. During the experiment, the most pronounced diuretic activity was observed for 4-nitrophe-nyl-O-β-D-glucopyranoside in a dose of 54 μmol/kg, which increased the diuresis in rats 2.5 times as compared to the control value.",

keywords = "Diuretics, Preclinical investigation",

author = "Smirnov, {I. V.} and Murashko, {T. O.} and Ivanov, {A. A.} and Nemtsev, {A. O.} and Bondarev, {A. A.} and Udut, {V. V.}",

year = "2015",

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language = "English",

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journal = "Eksperimental'naya i Klinicheskaya Farmakologiya",

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T1 - Searching for new synthetic diuretics

AU - Smirnov, I. V.

AU - Murashko, T. O.

AU - Ivanov, A. A.

AU - Nemtsev, A. O.

AU - Bondarev, A. A.

AU - Udut, V. V.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - This study was aimed at estimation of the diuretic and saluretic activity of 4-nitrophenyl-O-β-D-glucopyranoside and its aglicon 4-nitrophenol in rats. Test animals daily received 4-nitrophenyl-O-β-D-glucopyranoside (group 1) and 4-nitrophenol (group 2) intragastrically in 2 mL of distilled water in a dose of 18 μ mol/kg from 1st to 7th day and 54 |jmol/kg from 8th to 14th days. During the experiment, the most pronounced diuretic activity was observed for 4-nitrophe-nyl-O-β-D-glucopyranoside in a dose of 54 μmol/kg, which increased the diuresis in rats 2.5 times as compared to the control value.

AB - This study was aimed at estimation of the diuretic and saluretic activity of 4-nitrophenyl-O-β-D-glucopyranoside and its aglicon 4-nitrophenol in rats. Test animals daily received 4-nitrophenyl-O-β-D-glucopyranoside (group 1) and 4-nitrophenol (group 2) intragastrically in 2 mL of distilled water in a dose of 18 μ mol/kg from 1st to 7th day and 54 |jmol/kg from 8th to 14th days. During the experiment, the most pronounced diuretic activity was observed for 4-nitrophe-nyl-O-β-D-glucopyranoside in a dose of 54 μmol/kg, which increased the diuresis in rats 2.5 times as compared to the control value.

KW - Diuretics

KW - Preclinical investigation

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