@article{2ceb97f5983046a7ab8f9c5b80c78bb9,
title = "Search for Intracellular Sensors Involved in the Functioning of Monovalent Cations as Secondary Messengers",
abstract = "Maintenance of non-equilibrium Na+ and K+ distribution between cytoplasm and extracellular medium suggests existence of sensors responding with conformational transitions to the changes of these monovalent cations{\textquoteright} intracellular concentration. Molecular nature of monovalent cation sensors has been established in Na,K-ATPase, G-protein-coupled receptors, and heat shock proteins structural studies. Recently, it was found that changes in Na+ and K+ intracellular concentration are the key factors in the transcription and translation control, respectively. In this review, we summarize results of these studies and discuss physiological and pathophysiological significance of Nai+,Ki+-dependent gene expression regulation mechanism.",
keywords = "potassium, sodium, transcription, translation",
author = "Klimanova, {E. A.} and Sidorenko, {S. V.} and Tverskoi, {A. M.} and Shiyan, {A. A.} and Smolyaninova, {L. V.} and Kapilevich, {L. V.} and Gusakova, {S. V.} and Maksimov, {G. V.} and Lopina, {O. D.} and Orlov, {S. N.}",
note = "Funding Information: This work was supported by the Russian Science Foundation (project 16-15-10026-p, section “Physiological and pathophysiological significance of Na i + ,K i + -dependent mechanism of gene expression regulation”) and Russian Foundation for Basic Research (project 18-04-00063, sections “Identified sensors of monovalent cations”, “Sodium as transcription regulator”, and “Potassium as translation regulator”). Publisher Copyright: {\textcopyright} 2019, Pleiades Publishing, Ltd. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
month = nov,
day = "1",
doi = "10.1134/S0006297919110063",
language = "English",
volume = "84",
pages = "1280--1295",
journal = "Biochemistry. Biokhimiia",
issn = "0006-2979",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "11",
}