Same-day imaging using small proteins: Clinical experience and translational prospects in oncology

Ahmet Krasniqi, Matthias D’Huyvetter, Nick Devoogdt, Fredrik Y. Frejd, Jens Sörensen, Anna Orlova, Marleen Keyaerts, Vladimir Tolmachev

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Imaging of expression of therapeutic targets may enable stratification of patients for targeted treatments. The use of small radiolabeled probes based on the heavy-chain variable region of heavy-chain–only immunoglobulins or nonimmunoglobulin scaffolds permits rapid localization of radiotracers in tumors and rapid clearance from normal tissues. This makes high-contrast imaging possible on the day of injection. This mini review focuses on small proteins for radionuclide-based imaging that would allow same-day imaging, with the emphasis on clinical applications and promising preclinical developments within the field of oncology.

Original languageEnglish
Pages (from-to)885-891
Number of pages7
JournalJournal of Nuclear Medicine
Volume59
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018
Externally publishedYes

Keywords

  • Affibody
  • Nanobody
  • Radionuclide molecular imaging
  • Scaffold proteins

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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