Abstract
(Chemical Equation Presented) 3,4-Disubstituted and 3,4,5-trisubstituted isoxazoles have been formed from alkynes and nitrile oxides in a ruthenium(II)-catalyzed process (see scheme; cod=cycloocta-l,5-diene, Cp*=C5Me5). These reactions are experimentally simple, proceed at room temperature, and produce isoxazoles with excellent regioselectivity in high yield.
| Original language | English |
|---|---|
| Pages (from-to) | 8285-8287 |
| Number of pages | 3 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 47 |
| Issue number | 43 |
| DOIs | |
| Publication status | Published - 13 Oct 2008 |
| Externally published | Yes |
Keywords
- Cycloaddition
- Homogeneous catalysis
- Isoxazoles
- Nitrile oxides
- Ruthenium
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
Fingerprint Dive into the research topics of 'Ruthenium-catalyzed cycloaddition of nitrile oxides and alkynes: Practical synthesis of isoxazoles'. Together they form a unique fingerprint.
Cite this
Grecian, S., & Fokin, V. V. (2008). Ruthenium-catalyzed cycloaddition of nitrile oxides and alkynes: Practical synthesis of isoxazoles. Angewandte Chemie - International Edition, 47(43), 8285-8287. https://doi.org/10.1002/anie.200801920