Abstract
(Chemical Equation Presented) 3,4-Disubstituted and 3,4,5-trisubstituted isoxazoles have been formed from alkynes and nitrile oxides in a ruthenium(II)-catalyzed process (see scheme; cod=cycloocta-l,5-diene, Cp*=C5Me5). These reactions are experimentally simple, proceed at room temperature, and produce isoxazoles with excellent regioselectivity in high yield.
| Original language | English |
|---|---|
| Pages (from-to) | 8285-8287 |
| Number of pages | 3 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 47 |
| Issue number | 43 |
| DOIs | |
| Publication status | Published - 13 Oct 2008 |
| Externally published | Yes |
Fingerprint
Keywords
- Cycloaddition
- Homogeneous catalysis
- Isoxazoles
- Nitrile oxides
- Ruthenium
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
Cite this
Ruthenium-catalyzed cycloaddition of nitrile oxides and alkynes : Practical synthesis of isoxazoles. / Grecian, Scott; Fokin, Valery V.
In: Angewandte Chemie - International Edition, Vol. 47, No. 43, 13.10.2008, p. 8285-8287.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ruthenium-catalyzed cycloaddition of nitrile oxides and alkynes
T2 - Practical synthesis of isoxazoles
AU - Grecian, Scott
AU - Fokin, Valery V.
PY - 2008/10/13
Y1 - 2008/10/13
N2 - (Chemical Equation Presented) 3,4-Disubstituted and 3,4,5-trisubstituted isoxazoles have been formed from alkynes and nitrile oxides in a ruthenium(II)-catalyzed process (see scheme; cod=cycloocta-l,5-diene, Cp*=C5Me5). These reactions are experimentally simple, proceed at room temperature, and produce isoxazoles with excellent regioselectivity in high yield.
AB - (Chemical Equation Presented) 3,4-Disubstituted and 3,4,5-trisubstituted isoxazoles have been formed from alkynes and nitrile oxides in a ruthenium(II)-catalyzed process (see scheme; cod=cycloocta-l,5-diene, Cp*=C5Me5). These reactions are experimentally simple, proceed at room temperature, and produce isoxazoles with excellent regioselectivity in high yield.
KW - Cycloaddition
KW - Homogeneous catalysis
KW - Isoxazoles
KW - Nitrile oxides
KW - Ruthenium
UR - http://www.scopus.com/inward/record.url?scp=54249127727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54249127727&partnerID=8YFLogxK
U2 - 10.1002/anie.200801920
DO - 10.1002/anie.200801920
M3 - Article
C2 - 18814156
AN - SCOPUS:54249127727
VL - 47
SP - 8285
EP - 8287
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 43
ER -