Ruthenium-catalyzed cycloaddition of nitrile oxides and alkynes: Practical synthesis of isoxazoles

Scott Grecian, Valery V. Fokin

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136 Citations (Scopus)


(Chemical Equation Presented) 3,4-Disubstituted and 3,4,5-trisubstituted isoxazoles have been formed from alkynes and nitrile oxides in a ruthenium(II)-catalyzed process (see scheme; cod=cycloocta-l,5-diene, Cp*=C5Me5). These reactions are experimentally simple, proceed at room temperature, and produce isoxazoles with excellent regioselectivity in high yield.

Original languageEnglish
Pages (from-to)8285-8287
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number43
Publication statusPublished - 13 Oct 2008
Externally publishedYes



  • Cycloaddition
  • Homogeneous catalysis
  • Isoxazoles
  • Nitrile oxides
  • Ruthenium

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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