Ruthenium-catalyzed cycloaddition of aryl azides and alkynes

Lars Kyhn Rasmussen, Brant C. Boren, Valery V. Fokin

Research output: Contribution to journalArticle

240 Citations (Scopus)

Abstract

The formation of 1,5-disubstituted 1,2,3-triazoles from aryl azides and alkynes was readily accomplished using [Cp*RuCl]4 catalyst in dimethylformamide. It was also demonstrated that the reaction provided higher yields, cleaner product, and shorter reaction times when carried out under microwave irradiation.

Original languageEnglish
Pages (from-to)5337-5339
Number of pages3
JournalOrganic Letters
Volume9
Issue number26
DOIs
Publication statusPublished - 20 Dec 2007
Externally publishedYes

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Dimethylformamide
cleaners
Triazoles
Alkynes
Ruthenium
Microwave irradiation
Azides
Cycloaddition
Cycloaddition Reaction
cycloaddition
alkynes
Microwaves
reaction time
ruthenium
microwaves
catalysts
Catalysts
irradiation
products

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Rasmussen, L. K., Boren, B. C., & Fokin, V. V. (2007). Ruthenium-catalyzed cycloaddition of aryl azides and alkynes. Organic Letters, 9(26), 5337-5339. https://doi.org/10.1021/ol701912s

Ruthenium-catalyzed cycloaddition of aryl azides and alkynes. / Rasmussen, Lars Kyhn; Boren, Brant C.; Fokin, Valery V.

In: Organic Letters, Vol. 9, No. 26, 20.12.2007, p. 5337-5339.

Research output: Contribution to journalArticle

Rasmussen, LK, Boren, BC & Fokin, VV 2007, 'Ruthenium-catalyzed cycloaddition of aryl azides and alkynes', Organic Letters, vol. 9, no. 26, pp. 5337-5339. https://doi.org/10.1021/ol701912s
Rasmussen, Lars Kyhn ; Boren, Brant C. ; Fokin, Valery V. / Ruthenium-catalyzed cycloaddition of aryl azides and alkynes. In: Organic Letters. 2007 ; Vol. 9, No. 26. pp. 5337-5339.
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