Ruthenium-catalyzed cycloaddition of aryl azides and alkynes

Lars Kyhn Rasmussen, Brant C. Boren, Valery V. Fokin

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250 Citations (Scopus)

Abstract

The formation of 1,5-disubstituted 1,2,3-triazoles from aryl azides and alkynes was readily accomplished using [Cp*RuCl]4 catalyst in dimethylformamide. It was also demonstrated that the reaction provided higher yields, cleaner product, and shorter reaction times when carried out under microwave irradiation.

Original languageEnglish
Pages (from-to)5337-5339
Number of pages3
JournalOrganic Letters
Volume9
Issue number26
DOIs
Publication statusPublished - 20 Dec 2007
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Rasmussen, L. K., Boren, B. C., & Fokin, V. V. (2007). Ruthenium-catalyzed cycloaddition of aryl azides and alkynes. Organic Letters, 9(26), 5337-5339. https://doi.org/10.1021/ol701912s