Ruthenium-catalyzed cycloaddition of alkynes and organic azides

Li Zhang, Xinguo Chen, Peng Xue, Herman H Y Sun, Ian D. Williams, K. Barry Sharpless, Valery V. Fokin, Guochen Jia

Research output: Contribution to journalArticlepeer-review

844 Citations (Scopus)


Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective "fusion" of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this catalysis, resulting in fully substituted 1,2,3-triazoles.

Original languageEnglish
Pages (from-to)15998-15999
Number of pages2
JournalJournal of the American Chemical Society
Issue number46
Publication statusPublished - 23 Nov 2005
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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