Ruthenium-catalyzed cycloaddition of alkynes and organic azides

Li Zhang, Xinguo Chen, Peng Xue, Herman H Y Sun, Ian D. Williams, K. Barry Sharpless, Valery V. Fokin, Guochen Jia

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810 Citations (Scopus)


Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective "fusion" of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this catalysis, resulting in fully substituted 1,2,3-triazoles.

Original languageEnglish
Pages (from-to)15998-15999
Number of pages2
JournalJournal of the American Chemical Society
Issue number46
Publication statusPublished - 23 Nov 2005
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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    Zhang, L., Chen, X., Xue, P., Sun, H. H. Y., Williams, I. D., Sharpless, K. B., Fokin, V. V., & Jia, G. (2005). Ruthenium-catalyzed cycloaddition of alkynes and organic azides. Journal of the American Chemical Society, 127(46), 15998-15999.