Ruthenium-catalyzed cycloaddition of alkynes and organic azides

Li Zhang, Xinguo Chen, Peng Xue, Herman H Y Sun, Ian D. Williams, K. Barry Sharpless, Valery V. Fokin, Guochen Jia

Research output: Contribution to journalArticle

765 Citations (Scopus)

Abstract

Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective "fusion" of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this catalysis, resulting in fully substituted 1,2,3-triazoles.

Original languageEnglish
Pages (from-to)15998-15999
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number46
DOIs
Publication statusPublished - 23 Nov 2005
Externally publishedYes

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Triazoles
Alkynes
Ruthenium
Azides
Cycloaddition
Cycloaddition Reaction
Catalysis
Fusion reactions
Catalysts

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Zhang, L., Chen, X., Xue, P., Sun, H. H. Y., Williams, I. D., Sharpless, K. B., ... Jia, G. (2005). Ruthenium-catalyzed cycloaddition of alkynes and organic azides. Journal of the American Chemical Society, 127(46), 15998-15999. https://doi.org/10.1021/ja054114s

Ruthenium-catalyzed cycloaddition of alkynes and organic azides. / Zhang, Li; Chen, Xinguo; Xue, Peng; Sun, Herman H Y; Williams, Ian D.; Sharpless, K. Barry; Fokin, Valery V.; Jia, Guochen.

In: Journal of the American Chemical Society, Vol. 127, No. 46, 23.11.2005, p. 15998-15999.

Research output: Contribution to journalArticle

Zhang, L, Chen, X, Xue, P, Sun, HHY, Williams, ID, Sharpless, KB, Fokin, VV & Jia, G 2005, 'Ruthenium-catalyzed cycloaddition of alkynes and organic azides', Journal of the American Chemical Society, vol. 127, no. 46, pp. 15998-15999. https://doi.org/10.1021/ja054114s
Zhang L, Chen X, Xue P, Sun HHY, Williams ID, Sharpless KB et al. Ruthenium-catalyzed cycloaddition of alkynes and organic azides. Journal of the American Chemical Society. 2005 Nov 23;127(46):15998-15999. https://doi.org/10.1021/ja054114s
Zhang, Li ; Chen, Xinguo ; Xue, Peng ; Sun, Herman H Y ; Williams, Ian D. ; Sharpless, K. Barry ; Fokin, Valery V. ; Jia, Guochen. / Ruthenium-catalyzed cycloaddition of alkynes and organic azides. In: Journal of the American Chemical Society. 2005 ; Vol. 127, No. 46. pp. 15998-15999.
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