Role of sugar segments of molecules in the mechanism of realization of the diuretic effect of phenolic glycosides

Abstract

We studied diuretic and saluretic effects of new synthetic origin phenolic glycosides and their aglicones. Investigation of diuretic and saluretic activity of of 4-nitrophenyl-β-D-glucopyranoside, hydroquinone-O-β-D-glucopyranoside (arbutin) and their aglycon-4-nitrophenol and hydroquinone was conducted on white laboratory rats in vivarium Animals received drug 7 days. Baseline diuresis after administration of 2 mL of distilled water of experimental group accepted as a control. The quantity of urine output was measured a day after administration of the test substances. The concentration of sodium and potassium ions in the urine were determined by flame photometry. The data obtained indicate that investigated glycosides has high diuretic activity. Phenolic glycosides have a pronounced diuretic effect as opposed to their aglycones in rats.

Original language	English
Pages (from-to)	6402-6405
Number of pages	4
Journal	Journal of Engineering and Applied Sciences
Volume	12
Issue number	Specialissue3
DOIs	https://doi.org/10.3923/jeasci.2017.6402.6405
Publication status	Published - 1 Jan 2017

Keywords

Aquaretic
Arbutin
Diuretic
Pheholic glycoside
Rat glucose
Saluretic

ASJC Scopus subject areas

Engineering(all)

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10.3923/jeasci.2017.6402.6405

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Role of sugar segments of molecules in the mechanism of realization of the diuretic effect of phenolic glycosides. / Ivan, Smirnov; Tatiana, Murashko; Olga, Emanova; Vladimir, Smirnov; Alexey, Ivanov.

In: Journal of Engineering and Applied Sciences, Vol. 12, No. Specialissue3, 01.01.2017, p. 6402-6405.

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AU - Alexey, Ivanov

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