Abstract
We studied diuretic and saluretic effects of new synthetic origin phenolic glycosides and their aglicones. Investigation of diuretic and saluretic activity of of 4-nitrophenyl-β-D-glucopyranoside, hydroquinone-O-β-D-glucopyranoside (arbutin) and their aglycon-4-nitrophenol and hydroquinone was conducted on white laboratory rats in vivarium Animals received drug 7 days. Baseline diuresis after administration of 2 mL of distilled water of experimental group accepted as a control. The quantity of urine output was measured a day after administration of the test substances. The concentration of sodium and potassium ions in the urine were determined by flame photometry. The data obtained indicate that investigated glycosides has high diuretic activity. Phenolic glycosides have a pronounced diuretic effect as opposed to their aglycones in rats.
| Original language | English |
|---|---|
| Pages (from-to) | 6402-6405 |
| Number of pages | 4 |
| Journal | Journal of Engineering and Applied Sciences |
| Volume | 12 |
| Issue number | Specialissue3 |
| DOIs | |
| Publication status | Published - 1 Jan 2017 |
Fingerprint
Keywords
- Aquaretic
- Arbutin
- Diuretic
- Pheholic glycoside
- Rat glucose
- Saluretic
ASJC Scopus subject areas
- Engineering(all)
Cite this
Role of sugar segments of molecules in the mechanism of realization of the diuretic effect of phenolic glycosides. / Ivan, Smirnov; Tatiana, Murashko; Olga, Emanova; Vladimir, Smirnov; Alexey, Ivanov.
In: Journal of Engineering and Applied Sciences, Vol. 12, No. Specialissue3, 01.01.2017, p. 6402-6405.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of sugar segments of molecules in the mechanism of realization of the diuretic effect of phenolic glycosides
AU - Ivan, Smirnov
AU - Tatiana, Murashko
AU - Olga, Emanova
AU - Vladimir, Smirnov
AU - Alexey, Ivanov
PY - 2017/1/1
Y1 - 2017/1/1
N2 - We studied diuretic and saluretic effects of new synthetic origin phenolic glycosides and their aglicones. Investigation of diuretic and saluretic activity of of 4-nitrophenyl-β-D-glucopyranoside, hydroquinone-O-β-D-glucopyranoside (arbutin) and their aglycon-4-nitrophenol and hydroquinone was conducted on white laboratory rats in vivarium Animals received drug 7 days. Baseline diuresis after administration of 2 mL of distilled water of experimental group accepted as a control. The quantity of urine output was measured a day after administration of the test substances. The concentration of sodium and potassium ions in the urine were determined by flame photometry. The data obtained indicate that investigated glycosides has high diuretic activity. Phenolic glycosides have a pronounced diuretic effect as opposed to their aglycones in rats.
AB - We studied diuretic and saluretic effects of new synthetic origin phenolic glycosides and their aglicones. Investigation of diuretic and saluretic activity of of 4-nitrophenyl-β-D-glucopyranoside, hydroquinone-O-β-D-glucopyranoside (arbutin) and their aglycon-4-nitrophenol and hydroquinone was conducted on white laboratory rats in vivarium Animals received drug 7 days. Baseline diuresis after administration of 2 mL of distilled water of experimental group accepted as a control. The quantity of urine output was measured a day after administration of the test substances. The concentration of sodium and potassium ions in the urine were determined by flame photometry. The data obtained indicate that investigated glycosides has high diuretic activity. Phenolic glycosides have a pronounced diuretic effect as opposed to their aglycones in rats.
KW - Aquaretic
KW - Arbutin
KW - Diuretic
KW - Pheholic glycoside
KW - Rat glucose
KW - Saluretic
UR - http://www.scopus.com/inward/record.url?scp=85039778080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039778080&partnerID=8YFLogxK
U2 - 10.3923/jeasci.2017.6402.6405
DO - 10.3923/jeasci.2017.6402.6405
M3 - Article
VL - 12
SP - 6402
EP - 6405
JO - Journal of Engineering and Applied Sciences
JF - Journal of Engineering and Applied Sciences
SN - 1816-949X
IS - Specialissue3
ER -