Role of respiratory epithelium in the development of hyperreactivity of bronchial smooth muscles

L. V. Kapilevich, E. Yu D'yakova, L. M. Ogorodova, T. N. Zaitseva, A. E. Sazonov, A. V. Nosarev

Research output: Contribution to journalArticlepeer-review

Abstract

In guinea pigs sensitized with ovalbumin the respiratory epithelium lost its ability to modulate the responses of airway smooth muscles to histaminergic stimuli. Incubation of bronchial segments with IL-5 potenntiated the contractile responses of bronchial smooth muscles to histamine in both intact and sensitized animals. Incubation of bronchial segments with IL-5 receptors moderated contractile activity of segments from sensitized pigs, but not in the segments from intact controls.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume140
Issue number3
DOIs
Publication statusPublished - Sep 2005

Keywords

  • Hyperreactivity
  • Respiratory epithelium
  • Smooth muscle

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Role of respiratory epithelium in the development of hyperreactivity of bronchial smooth muscles'. Together they form a unique fingerprint.

Cite this