Role of Opiate Receptors and ATP-Dependent Potassium Channels of Mitochondria in the Formation of Myocardial Adaptive Resistance to the Arrhythmogenic Effect of Ischemia and Reperfusion

Yu B. Lishmanov, N. V. Naryzhnaya, A. B. Krylatov, L. N. Maslov, S. A. Bogomaz, D. S. Ugdyzhekova, G. J. Gross, J. B. Stefano

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Preliminary stimulation of opiate receptors (ORs) by intravenous administration of μ agonist DALDA (0.5 mg/kg), δ1 agonist DPDPE (0.5 mg/kg), and κ agonist (-)-U-50.488 (1 mg/kg) increases rat myocardial resistance to arrhythmogenic effect of coronary occlusion (10 min) and reperfusion (10 min). Activation of δ2 ORs (DSLET, 0.5 mg/kg) has no effect on the incidence rate of ischemic and reperfusion arrhythmias. Preliminary administration of glibenclamide (0.3 mg/kg), an inhibitor of KATP channels, blocks the antiarrhythmic effect of DALDA and DPDPE. Repeated short-term exposures of rats to immobilization within two weeks increases the heart tolerance to the arrhythmogenic effect of coronary occlusion and reperfusion. This effect disappears after administration of CTAP (0.5 mg/kg), a μ antagonist, or injection of 5-hydroxydecanoate (5 mg/kg), an inhibitor of mitochondrial KATP channels. The selective antagonists of δ and κ ORs have no effect on cardiac adaptation-induced resistance to the arrhythmogenic effect of ischemia and reperfusion. We believe that stimulation of μ, δ, and κ ORs increases myocardial tolerance to the arrhythmogenic effect of ischemia and reperfusion through activation of KATP channels. The antiarrhythmic effect of the adaptation is mediated by stimulation of μ ORs and mitochondrial KATP channels.

Original languageEnglish
Pages (from-to)603-609
Number of pages7
JournalBiology Bulletin
Issue number6
Publication statusPublished - 1 Nov 2003


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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