Role of eNOS in water exchange index maintenance-MRI studies

Abstract

Stroke studies employ experimental models of cerebral ischemic and reperfusion injury in rodents. MRI provides valuable supravital data of cerebral blood flow and brain tissue damage. This paper presents MRI applications for cerebral blood flow research in mice lines with impaired nitric oxide production by endothelial nitric oxide synthase. Our data demonstrates that specific modifications of MRI methodology in transgenic mouse models help to evaluate the role of eNOS in the brain-blood barrier function.

Original language	English
Article number	012002
Journal	Journal of Physics: Conference Series
Volume	886
Issue number	1
DOIs	https://doi.org/10.1088/1742-6596/886/1/012002
Publication status	Published - 29 Aug 2017
Event	3rd International Conference and Young Scientist School on Magnetic Resonance Imaging in Biomedical Research, MRIBiomed 2016 - Novosibirsk, Russian Federation Duration: 23 Nov 2016 → 26 Nov 2016

ASJC Scopus subject areas

Physics and Astronomy(all)

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10.1088/1742-6596/886/1/012002

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title = "Role of eNOS in water exchange index maintenance-MRI studies",

abstract = "Stroke studies employ experimental models of cerebral ischemic and reperfusion injury in rodents. MRI provides valuable supravital data of cerebral blood flow and brain tissue damage. This paper presents MRI applications for cerebral blood flow research in mice lines with impaired nitric oxide production by endothelial nitric oxide synthase. Our data demonstrates that specific modifications of MRI methodology in transgenic mouse models help to evaluate the role of eNOS in the brain-blood barrier function.",

author = "D. Atochin and M. Litvak and S. Huang and Kim, {Y. R.} and P. Huang",

year = "2017",

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AB - Stroke studies employ experimental models of cerebral ischemic and reperfusion injury in rodents. MRI provides valuable supravital data of cerebral blood flow and brain tissue damage. This paper presents MRI applications for cerebral blood flow research in mice lines with impaired nitric oxide production by endothelial nitric oxide synthase. Our data demonstrates that specific modifications of MRI methodology in transgenic mouse models help to evaluate the role of eNOS in the brain-blood barrier function.

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