Role of endothelial nitric oxide in cerebrovascular regulation

Dmitriy N. Atochin, Paul L. Huang

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Endothelial nitric oxide (NO) plays important roles in the vascular system. Animal models that show vascular dysfunction demonstrate the protective role of endothelial NO dependent pathways. This review focuses on the role of endothelial NO in the regulation of cerebral blood flow and vascular tone. We will discuss the importance of NO in cerebrovascular function using animal models with altered endothelial NO production under normal, ischemic and reperfusion conditions, as well as in hyperoxia. Pharmacological and genetic manipulations of the endothelial NO system demonstrate the essential roles of endothelial NO synthase in maintenance of vascular tone and cerebral perfusion under normal and pathological conditions.

Original languageEnglish
Pages (from-to)1334-1342
Number of pages9
JournalCurrent Pharmaceutical Biotechnology
Volume12
Issue number9
Publication statusPublished - Sep 2011
Externally publishedYes

Keywords

  • Cerebrovascular regulation
  • Endothelial nitric oxide synthase
  • Mutant mice

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Biotechnology

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