Role of endogenous opioid receptor agonists in regulation of heart resistence to the arrhythmogenic action of short-term ischemia and reperfusion

L. N. Maslov, Yu B. Lishmanov, N. V. Naryzhnaya, E. V. Budankova, D. L. Stakheev, N. V. Solenkova, E. I. Barzakh, P. R. Oeltgen, G. J. Gross

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Preliminary selective block of μ-, δ1-, δ2-, and κ-opioid receptors had no effect on the incidence of ventricular arrhythmias during 10-min coronary occlusion-reperfusion in ketamine-narcotized rats. Repetitive short-term immobilization of rats for 2 weeks improved heart resistance to the arrhythmogenic action of coronary occlusion and reperfusion. Selective μ-opioid receptor antagonist CTAP completely abolished, while selective δ- and κ-opioid receptor antagonists did not modulate the antiarrhythmic effect of adaptation. Probably, endogenous agonists of μ-opioid receptors play an important role in the adaptive improvement of heart resistance to arrhythmogenic factors, but are insignificant for the modulation of heart resistance to the arrhythmogenic action of short-term local ischemia-reperfusion in non-adapted animals.

Original languageEnglish
Pages (from-to)172-175
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume139
Issue number2
DOIs
Publication statusPublished - 1 Feb 2005

Keywords

  • Arrhythmia
  • Heart
  • Ischemia
  • Opioid receptors
  • Reperfusion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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